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The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment
In the past few decades, great progress has been achieved in the understanding of microbiome-cancer interactions. However, most of the studies have focused on the gut microbiome, ignoring how other microbiomes interact with tumors. Emerging evidence suggests that in many types of cancers, such as lu...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718533/ https://www.ncbi.nlm.nih.gov/pubmed/36466871 http://dx.doi.org/10.3389/fimmu.2022.1051987 |
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author | Gao, Feng Yu, Bo Rao, Benchen Sun, Ying Yu, Jia Wang, Daming Cui, Guangying Ren, Zhigang |
author_facet | Gao, Feng Yu, Bo Rao, Benchen Sun, Ying Yu, Jia Wang, Daming Cui, Guangying Ren, Zhigang |
author_sort | Gao, Feng |
collection | PubMed |
description | In the past few decades, great progress has been achieved in the understanding of microbiome-cancer interactions. However, most of the studies have focused on the gut microbiome, ignoring how other microbiomes interact with tumors. Emerging evidence suggests that in many types of cancers, such as lung cancer, pancreatic cancer, and colorectal cancer, the intratumoral microbiome plays a significant role. In addition, accumulating evidence suggests that intratumoral microbes have multiple effects on the biological behavior of tumors, for example, regulating tumor initiation and progression and altering the tumor response to chemotherapy and immunotherapy. However, to fully understand the role of the intratumoral microbiome in cancer, further investigation of the effects and mechanisms is still needed. This review discusses the role of intratumoral bacteria in tumorigenesis and tumor progression, recurrence and metastasis, as well as their effect on cancer prognosis and treatment outcome, and summarizes the relevant mechanisms. |
format | Online Article Text |
id | pubmed-9718533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97185332022-12-03 The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment Gao, Feng Yu, Bo Rao, Benchen Sun, Ying Yu, Jia Wang, Daming Cui, Guangying Ren, Zhigang Front Immunol Immunology In the past few decades, great progress has been achieved in the understanding of microbiome-cancer interactions. However, most of the studies have focused on the gut microbiome, ignoring how other microbiomes interact with tumors. Emerging evidence suggests that in many types of cancers, such as lung cancer, pancreatic cancer, and colorectal cancer, the intratumoral microbiome plays a significant role. In addition, accumulating evidence suggests that intratumoral microbes have multiple effects on the biological behavior of tumors, for example, regulating tumor initiation and progression and altering the tumor response to chemotherapy and immunotherapy. However, to fully understand the role of the intratumoral microbiome in cancer, further investigation of the effects and mechanisms is still needed. This review discusses the role of intratumoral bacteria in tumorigenesis and tumor progression, recurrence and metastasis, as well as their effect on cancer prognosis and treatment outcome, and summarizes the relevant mechanisms. Frontiers Media S.A. 2022-11-18 /pmc/articles/PMC9718533/ /pubmed/36466871 http://dx.doi.org/10.3389/fimmu.2022.1051987 Text en Copyright © 2022 Gao, Yu, Rao, Sun, Yu, Wang, Cui and Ren https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Gao, Feng Yu, Bo Rao, Benchen Sun, Ying Yu, Jia Wang, Daming Cui, Guangying Ren, Zhigang The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment |
title | The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment |
title_full | The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment |
title_fullStr | The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment |
title_full_unstemmed | The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment |
title_short | The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment |
title_sort | effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718533/ https://www.ncbi.nlm.nih.gov/pubmed/36466871 http://dx.doi.org/10.3389/fimmu.2022.1051987 |
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