Single-cell genome-wide association reveals that a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus

During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human in vitro susceptibility testing (scHi-HOST), a method for rapidly identifying genetic variants that confer resistance and susceptibility. We applied this method to in...

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Detalles Bibliográficos
Autores principales: Schott, Benjamin H., Wang, Liuyang, Zhu, Xinyu, Harding, Alfred T., Ko, Emily R., Bourgeois, Jeffrey S., Washington, Erica J., Burke, Thomas W., Anderson, Jack, Bergstrom, Emma, Gardener, Zoe, Paterson, Suzanna, Brennan, Richard G., Chiu, Christopher, McClain, Micah T., Woods, Christopher W., Gregory, Simon G., Heaton, Nicholas S., Ko, Dennis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718543/
https://www.ncbi.nlm.nih.gov/pubmed/36465279
http://dx.doi.org/10.1016/j.xgen.2022.100207

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