Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response—An Unusual Case Report

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder that develops from the stem cell compartment. The classical translocation ( BCR-ABL1 ) is present in approximately 95% of CML patients. Through disease progression, clonal evolution with additional chromosomal abnormalities (ACAs...

Descripción completa

Detalles Bibliográficos
Autores principales: Bharathi Devi, Goranthala, Jayachandran, Perumal Kalaiyarasi, Arumugam, Jhansi Rani, Bommannan, Karthik, Sundersingh, Shirley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718595/
https://www.ncbi.nlm.nih.gov/pubmed/36466981
http://dx.doi.org/10.1055/s-0041-1739178
_version_ 1784843120768188416
author Bharathi Devi, Goranthala
Jayachandran, Perumal Kalaiyarasi
Arumugam, Jhansi Rani
Bommannan, Karthik
Sundersingh, Shirley
author_facet Bharathi Devi, Goranthala
Jayachandran, Perumal Kalaiyarasi
Arumugam, Jhansi Rani
Bommannan, Karthik
Sundersingh, Shirley
author_sort Bharathi Devi, Goranthala
collection PubMed
description Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder that develops from the stem cell compartment. The classical translocation ( BCR-ABL1 ) is present in approximately 95% of CML patients. Through disease progression, clonal evolution with additional chromosomal abnormalities (ACAs) start appearing. Although relatively rare, chromosomal abnormalities can exist or develop in the Philadelphia (Ph)-negative clones, which may lead to the evolution of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). We hereby present a case of AML which emerged from a Ph-negative clone in a patient with a history of CML who was in deep molecular response. The possible mechanisms of ACAs have been discussed.
format Online
Article
Text
id pubmed-9718595
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
record_format MEDLINE/PubMed
spelling pubmed-97185952022-12-03 Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response—An Unusual Case Report Bharathi Devi, Goranthala Jayachandran, Perumal Kalaiyarasi Arumugam, Jhansi Rani Bommannan, Karthik Sundersingh, Shirley South Asian J Cancer Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder that develops from the stem cell compartment. The classical translocation ( BCR-ABL1 ) is present in approximately 95% of CML patients. Through disease progression, clonal evolution with additional chromosomal abnormalities (ACAs) start appearing. Although relatively rare, chromosomal abnormalities can exist or develop in the Philadelphia (Ph)-negative clones, which may lead to the evolution of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). We hereby present a case of AML which emerged from a Ph-negative clone in a patient with a history of CML who was in deep molecular response. The possible mechanisms of ACAs have been discussed. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-03-22 /pmc/articles/PMC9718595/ /pubmed/36466981 http://dx.doi.org/10.1055/s-0041-1739178 Text en MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Bharathi Devi, Goranthala
Jayachandran, Perumal Kalaiyarasi
Arumugam, Jhansi Rani
Bommannan, Karthik
Sundersingh, Shirley
Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response—An Unusual Case Report
title Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response—An Unusual Case Report
title_full Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response—An Unusual Case Report
title_fullStr Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response—An Unusual Case Report
title_full_unstemmed Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response—An Unusual Case Report
title_short Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response—An Unusual Case Report
title_sort secondary acute myeloid leukemia in a chronic myeloid leukemia patient in deep molecular response—an unusual case report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718595/
https://www.ncbi.nlm.nih.gov/pubmed/36466981
http://dx.doi.org/10.1055/s-0041-1739178
work_keys_str_mv AT bharathidevigoranthala secondaryacutemyeloidleukemiainachronicmyeloidleukemiapatientindeepmolecularresponseanunusualcasereport
AT jayachandranperumalkalaiyarasi secondaryacutemyeloidleukemiainachronicmyeloidleukemiapatientindeepmolecularresponseanunusualcasereport
AT arumugamjhansirani secondaryacutemyeloidleukemiainachronicmyeloidleukemiapatientindeepmolecularresponseanunusualcasereport
AT bommannankarthik secondaryacutemyeloidleukemiainachronicmyeloidleukemiapatientindeepmolecularresponseanunusualcasereport
AT sundersinghshirley secondaryacutemyeloidleukemiainachronicmyeloidleukemiapatientindeepmolecularresponseanunusualcasereport

Ejemplares similares