Cargando…

The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma

Background  Oral metronomic chemotherapy (OMCT) represents an emerging concept in cancer treatment involving frequent administration of chemotherapeutic drugs at doses below maximum tolerated doses and with no prolonged drug-free break. OMCT is being tried preoperatively in developing nations with c...

Descripción completa

Detalles Bibliográficos
Autores principales: Aravind, Sithara, Jose, Jasmin, Shenoy, Praveen Kumar, Avaronnan, Manuprasad, Thavarool, Sajith Babu, Nayanar, Sangeetha K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718607/
https://www.ncbi.nlm.nih.gov/pubmed/36466986
http://dx.doi.org/10.1055/s-0041-1735592
_version_ 1784843123886653440
author Aravind, Sithara
Jose, Jasmin
Shenoy, Praveen Kumar
Avaronnan, Manuprasad
Thavarool, Sajith Babu
Nayanar, Sangeetha K.
author_facet Aravind, Sithara
Jose, Jasmin
Shenoy, Praveen Kumar
Avaronnan, Manuprasad
Thavarool, Sajith Babu
Nayanar, Sangeetha K.
author_sort Aravind, Sithara
collection PubMed
description Background  Oral metronomic chemotherapy (OMCT) represents an emerging concept in cancer treatment involving frequent administration of chemotherapeutic drugs at doses below maximum tolerated doses and with no prolonged drug-free break. OMCT is being tried preoperatively in developing nations with constrained resources to prevent disease progression during the waiting period from diagnosis to surgery (bridge OMCT). The aim of the present study was to assess the spectrum of histomorphological changes and pathological tumor response following bridge OMCT in oral squamous cell carcinoma (OSCC) and to propose a new pathological response scoring system. Materials and Methods  A retrospective single-center study comprised of tissue sections of tumor proper and metastatic lymph nodes of 50, locally advanced OSCC patients treated with bridge OMCT, and had completed definitive surgery were analyzed. The present study evaluated the histomorphological features and proposed a new scoring system for pathologic tumor response. The pathologic tumor response was categorized as complete response (pCR), no response (pNR), and partial response (pPR). Results  Of the total 50 patients, 2 patients had pCR, 3 had pNR, and 45 patients had pPR as per the new proposed scoring system. Note that 96% of the cases showed no disease progression. Conclusion  Bridge OMCT is a novel treatment method that can be used to tide over the waiting period between the diagnosis and surgery in resource-constrained institutions with heavy patient load. This mode of treatment in locally advanced OSCC seems to provide promising results in this setting. Large multicentric trials are warranted to confirm these results.
format Online
Article
Text
id pubmed-9718607
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
record_format MEDLINE/PubMed
spelling pubmed-97186072022-12-03 The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma Aravind, Sithara Jose, Jasmin Shenoy, Praveen Kumar Avaronnan, Manuprasad Thavarool, Sajith Babu Nayanar, Sangeetha K. South Asian J Cancer Background  Oral metronomic chemotherapy (OMCT) represents an emerging concept in cancer treatment involving frequent administration of chemotherapeutic drugs at doses below maximum tolerated doses and with no prolonged drug-free break. OMCT is being tried preoperatively in developing nations with constrained resources to prevent disease progression during the waiting period from diagnosis to surgery (bridge OMCT). The aim of the present study was to assess the spectrum of histomorphological changes and pathological tumor response following bridge OMCT in oral squamous cell carcinoma (OSCC) and to propose a new pathological response scoring system. Materials and Methods  A retrospective single-center study comprised of tissue sections of tumor proper and metastatic lymph nodes of 50, locally advanced OSCC patients treated with bridge OMCT, and had completed definitive surgery were analyzed. The present study evaluated the histomorphological features and proposed a new scoring system for pathologic tumor response. The pathologic tumor response was categorized as complete response (pCR), no response (pNR), and partial response (pPR). Results  Of the total 50 patients, 2 patients had pCR, 3 had pNR, and 45 patients had pPR as per the new proposed scoring system. Note that 96% of the cases showed no disease progression. Conclusion  Bridge OMCT is a novel treatment method that can be used to tide over the waiting period between the diagnosis and surgery in resource-constrained institutions with heavy patient load. This mode of treatment in locally advanced OSCC seems to provide promising results in this setting. Large multicentric trials are warranted to confirm these results. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-02-02 /pmc/articles/PMC9718607/ /pubmed/36466986 http://dx.doi.org/10.1055/s-0041-1735592 Text en MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Aravind, Sithara
Jose, Jasmin
Shenoy, Praveen Kumar
Avaronnan, Manuprasad
Thavarool, Sajith Babu
Nayanar, Sangeetha K.
The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma
title The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma
title_full The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma
title_fullStr The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma
title_full_unstemmed The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma
title_short The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma
title_sort spectrum of histomorphological changes and pathological tumor response following preoperative oral metronomic chemotherapy in oral squamous cell carcinoma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718607/
https://www.ncbi.nlm.nih.gov/pubmed/36466986
http://dx.doi.org/10.1055/s-0041-1735592
work_keys_str_mv AT aravindsithara thespectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma
AT josejasmin thespectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma
AT shenoypraveenkumar thespectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma
AT avaronnanmanuprasad thespectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma
AT thavaroolsajithbabu thespectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma
AT nayanarsangeethak thespectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma
AT aravindsithara spectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma
AT josejasmin spectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma
AT shenoypraveenkumar spectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma
AT avaronnanmanuprasad spectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma
AT thavaroolsajithbabu spectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma
AT nayanarsangeethak spectrumofhistomorphologicalchangesandpathologicaltumorresponsefollowingpreoperativeoralmetronomicchemotherapyinoralsquamouscellcarcinoma