Targeting the cholesterol-RORα/γ axis inhibits colorectal cancer progression through degrading c-myc

Dysregulated cholesterol metabolism is a hallmark of colorectal cancer (CRC). However, the usage of cholesterol-lowering agents seemed to have no benefit in CRC patients. In this study, we focused on the cholesterol-nuclear receptors (NRs) axis as a strategy. Cholesterol and its derivatives work as...

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Detalles Bibliográficos
Autores principales: Wang, Ying-Nan, Ruan, Dan-Yun, Wang, Zi-Xian, Yu, Kai, Rong, Dai-Lin, Liu, Ze-Xian, Wang, Feng, Hu, Jia-Jia, Jin, Ying, Wu, Qi-Nian, Pu, Heng-Ying, Wang, Min, Xu, Rui-Hua, Zeng, Zhao-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718673/
https://www.ncbi.nlm.nih.gov/pubmed/36316442
http://dx.doi.org/10.1038/s41388-022-02515-3

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