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Protein-Peptide Turnover Profiling reveals the order of PTM addition and removal during protein maturation
Post-translational modifications (PTMs) regulate various aspects of protein function, including degradation. Mass spectrometric methods relying on pulsed metabolic labeling are popular to quantify turnover rates on a proteome-wide scale. Such data have traditionally been interpreted in the context o...
Autores principales: | Hammarén, Henrik M., Geissen, Eva-Maria, Potel, Clement M., Beck, Martin, Savitski, Mikhail M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718778/ https://www.ncbi.nlm.nih.gov/pubmed/36460637 http://dx.doi.org/10.1038/s41467-022-35054-2 |
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