Discrete LAT condensates encode antigen information from single pMHC:TCR binding events

LAT assembly into a two-dimensional protein condensate is a prominent feature of antigen discrimination by T cells. Here, we use single-molecule imaging techniques to resolve the spatial position and temporal duration of each pMHC:TCR molecular binding event while simultaneously monitoring LAT conde...

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Detalles Bibliográficos
Autores principales: McAffee, Darren B., O’Dair, Mark K., Lin, Jenny J., Low-Nam, Shalini T., Wilhelm, Kiera B., Kim, Sungi, Morita, Shumpei, Groves, Jay T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718779/
https://www.ncbi.nlm.nih.gov/pubmed/36460640
http://dx.doi.org/10.1038/s41467-022-35093-9

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