Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics

Caffeic acid derivatives containing amide moieties similar to those of finasteride and dutasteride were synthesized. An in vitro inhibitory activity evaluation of caffeic acid (1) and its amide derivatives (2 − 4) against the steroid 5α-reductase type 1 (SRD5A1) produced by human keratinocyte cells...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Aye Chan Khine, Netcharoensirisuk, Ponsawan, Sanachai, Kamonpan, Sukma, Warongrit, Chansriniyom, Chaisak, Chaotham, Chatchai, De-Eknamkul, Wanchai, Rungrotmongkol, Thanyada, Chamni, Supakarn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718795/
https://www.ncbi.nlm.nih.gov/pubmed/36460729
http://dx.doi.org/10.1038/s41598-022-25335-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718795/
https://www.ncbi.nlm.nih.gov/pubmed/36460729
http://dx.doi.org/10.1038/s41598-022-25335-7

Ejemplares similares