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A quantitative model for the dynamics of target recognition and off-target rejection by the CRISPR-Cas Cascade complex

CRISPR-Cas effector complexes recognise nucleic acid targets by base pairing with their crRNA which enables easy re-programming of the target specificity in rapidly emerging genome engineering applications. However, undesired recognition of off-targets, that are only partially complementary to the c...

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Detalles Bibliográficos
Autores principales:	Rutkauskas, Marius, Songailiene, Inga, Irmisch, Patrick, Kemmerich, Felix E., Sinkunas, Tomas, Siksnys, Virginijus, Seidel, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718816/ https://www.ncbi.nlm.nih.gov/pubmed/36460652 http://dx.doi.org/10.1038/s41467-022-35116-5

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