DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal

Mechanisms by which specific histone modifications regulate distinct gene networks remain little understood. We investigated how H3K79me2, a modification catalyzed by DOT1L and previously considered a general transcriptional activation mark, regulates gene expression during cardiogenesis. Embryonic...

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Detalles Bibliográficos
Autores principales: Cattaneo, Paola, Hayes, Michael G. B., Baumgarten, Nina, Hecker, Dennis, Peruzzo, Sofia, Aslan, Galip S., Kunderfranco, Paolo, Larcher, Veronica, Zhang, Lunfeng, Contu, Riccardo, Fonseca, Gregory, Spinozzi, Simone, Chen, Ju, Condorelli, Gianluigi, Dimmeler, Stefanie, Schulz, Marcel H., Heinz, Sven, Guimarães-Camboa, Nuno, Evans, Sylvia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718823/
https://www.ncbi.nlm.nih.gov/pubmed/36460641
http://dx.doi.org/10.1038/s41467-022-35070-2

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