Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation

Pluripotent stem cells hold great promise in regenerative medicine and developmental biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle intermediates, have been reported to play critical roles in pluripotency. Here we show that TCA cycle enzymes including Pdha1, Pcb...

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Detalles Bibliográficos
Autores principales: Li, Wei, Long, Qi, Wu, Hao, Zhou, Yanshuang, Duan, Lifan, Yuan, Hao, Ding, Yingzhe, Huang, Yile, Wu, Yi, Huang, Jinyu, Liu, Delong, Chen, Baodan, Zhang, Jian, Qi, Juntao, Du, Shiwei, Li, Linpeng, Liu, Yang, Ruan, Zifeng, Liu, Zihuang, Liu, Zichao, Zhao, Yifan, Lu, Jianghuan, Wang, Junwei, Chan, Wai-Yee, Liu, Xingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718843/
https://www.ncbi.nlm.nih.gov/pubmed/36460681
http://dx.doi.org/10.1038/s41467-022-35199-0

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