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Pan-cancer analysis based on epigenetic modification explains the value of HJURP in the tumor microenvironment
To analyze the expression levels, prognostic value and immune infiltration association of Holliday junction protein (HJURP) as well as its feasibility as a pan-cancer biomarker for different cancers. The Protter online tool was utilized to obtain the localization of HJURP, then the methylation of HJ...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718852/ https://www.ncbi.nlm.nih.gov/pubmed/36460821 http://dx.doi.org/10.1038/s41598-022-25439-0 |
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author | Li, Junwu Zheng, Jun Zhang, Ronggui Zhang, Weili Zhang, Junyong Zhang, Yuanfeng |
author_facet | Li, Junwu Zheng, Jun Zhang, Ronggui Zhang, Weili Zhang, Junyong Zhang, Yuanfeng |
author_sort | Li, Junwu |
collection | PubMed |
description | To analyze the expression levels, prognostic value and immune infiltration association of Holliday junction protein (HJURP) as well as its feasibility as a pan-cancer biomarker for different cancers. The Protter online tool was utilized to obtain the localization of HJURP, then the methylation of HJURP in tumors were further explored. Thereafter, the mRNA data and clinical characteristics of 33 tumor types from TCGA database were obtained to investigate the expression and prognostic relationship of HJURP in different tumor types. Finally, the composition pattern and immune infiltration of HJURP in different tumors were detected in Tumor Immune Estimation Resource. HJURP was abnormally expressed in most of the cancer types and subtypes in TCGA database. Also, it was associated with poor prognosis of different cohorts. At the same time, the results also showed that HJURP was related to tumor immune evasion through different mechanisms, including T cell rejection and methylation in different cancer types. Besides, the methylation of HJURP was inversely proportional to mRNA expression levels, which mediated the dysfunctional phenotypes of T cells and poor prognosis of different cancer types. Alternatively, our results indicated that HJURP expression was associated with immune cell infiltration in a variety of cancers. HJURP may serve as an oncogenic molecule, and its expression and immune infiltration characteristics can be used as a biomarker for cancer detection, prognosis, treatment design and follow-up. |
format | Online Article Text |
id | pubmed-9718852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97188522022-12-04 Pan-cancer analysis based on epigenetic modification explains the value of HJURP in the tumor microenvironment Li, Junwu Zheng, Jun Zhang, Ronggui Zhang, Weili Zhang, Junyong Zhang, Yuanfeng Sci Rep Article To analyze the expression levels, prognostic value and immune infiltration association of Holliday junction protein (HJURP) as well as its feasibility as a pan-cancer biomarker for different cancers. The Protter online tool was utilized to obtain the localization of HJURP, then the methylation of HJURP in tumors were further explored. Thereafter, the mRNA data and clinical characteristics of 33 tumor types from TCGA database were obtained to investigate the expression and prognostic relationship of HJURP in different tumor types. Finally, the composition pattern and immune infiltration of HJURP in different tumors were detected in Tumor Immune Estimation Resource. HJURP was abnormally expressed in most of the cancer types and subtypes in TCGA database. Also, it was associated with poor prognosis of different cohorts. At the same time, the results also showed that HJURP was related to tumor immune evasion through different mechanisms, including T cell rejection and methylation in different cancer types. Besides, the methylation of HJURP was inversely proportional to mRNA expression levels, which mediated the dysfunctional phenotypes of T cells and poor prognosis of different cancer types. Alternatively, our results indicated that HJURP expression was associated with immune cell infiltration in a variety of cancers. HJURP may serve as an oncogenic molecule, and its expression and immune infiltration characteristics can be used as a biomarker for cancer detection, prognosis, treatment design and follow-up. Nature Publishing Group UK 2022-12-02 /pmc/articles/PMC9718852/ /pubmed/36460821 http://dx.doi.org/10.1038/s41598-022-25439-0 Text en © The Author(s) 2022, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Junwu Zheng, Jun Zhang, Ronggui Zhang, Weili Zhang, Junyong Zhang, Yuanfeng Pan-cancer analysis based on epigenetic modification explains the value of HJURP in the tumor microenvironment |
title | Pan-cancer analysis based on epigenetic modification explains the value of HJURP in the tumor microenvironment |
title_full | Pan-cancer analysis based on epigenetic modification explains the value of HJURP in the tumor microenvironment |
title_fullStr | Pan-cancer analysis based on epigenetic modification explains the value of HJURP in the tumor microenvironment |
title_full_unstemmed | Pan-cancer analysis based on epigenetic modification explains the value of HJURP in the tumor microenvironment |
title_short | Pan-cancer analysis based on epigenetic modification explains the value of HJURP in the tumor microenvironment |
title_sort | pan-cancer analysis based on epigenetic modification explains the value of hjurp in the tumor microenvironment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718852/ https://www.ncbi.nlm.nih.gov/pubmed/36460821 http://dx.doi.org/10.1038/s41598-022-25439-0 |
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