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Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease

Thymic selection and peripheral activation of conventional T (Tconv) and regulatory T (Treg) cells depend on TCR signaling, whose anomalies are causative of autoimmunity. Here, we expressed in normal mice mutated ZAP-70 molecules with different affinities for the CD3 chains, or wild type ZAP-70 at g...

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Detalles Bibliográficos
Autores principales:	Tanaka, Atsushi, Maeda, Shinji, Nomura, Takashi, Llamas-Covarrubias, Mara Anais, Tanaka, Satoshi, Jin, Lin, Lim, Ee Lyn, Morikawa, Hiromasa, Kitagawa, Yohko, Akizuki, Shuji, Ito, Yoshinaga, Fujimori, Chihiro, Hirota, Keiji, Murase, Tosei, Hashimoto, Motomu, Higo, Junichi, Zamoyska, Rose, Ueda, Ryuzo, Standley, Daron M., Sakaguchi, Noriko, Sakaguchi, Shimon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718937/ https://www.ncbi.nlm.nih.gov/pubmed/36454183 http://dx.doi.org/10.1084/jem.20220386

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