Remarkable Intracranial Response to Sotorasib in a Patient With KRAS(G12C)-Mutated Lung Adenocarcinoma and Untreated Brain Metastases: A Case Report

Sotorasib is a KRAS(G12C) inhibitor that recently received approval for use in locally advanced or metastatic KRAS(G12C)-mutated NSCLC. CodeBreaK100, the phase 2 clinical trial leading to the approval of sotorasib, excluded patients with untreated brain metastases; there have been no reports describ...

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Autores principales: Yeh, Justin, Marks, Jennifer A., Alzeer, Ali H., Sloan, Emily A., Varghese, Reshma, Paudel, Nitika, Reuss, Joshua E., Bergquist, Peter J., Liu, Stephen V., Kim, Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719091/
https://www.ncbi.nlm.nih.gov/pubmed/36471683
http://dx.doi.org/10.1016/j.jtocrr.2022.100428
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author Yeh, Justin
Marks, Jennifer A.
Alzeer, Ali H.
Sloan, Emily A.
Varghese, Reshma
Paudel, Nitika
Reuss, Joshua E.
Bergquist, Peter J.
Liu, Stephen V.
Kim, Chul
author_facet Yeh, Justin
Marks, Jennifer A.
Alzeer, Ali H.
Sloan, Emily A.
Varghese, Reshma
Paudel, Nitika
Reuss, Joshua E.
Bergquist, Peter J.
Liu, Stephen V.
Kim, Chul
author_sort Yeh, Justin
collection PubMed
description Sotorasib is a KRAS(G12C) inhibitor that recently received approval for use in locally advanced or metastatic KRAS(G12C)-mutated NSCLC. CodeBreaK100, the phase 2 clinical trial leading to the approval of sotorasib, excluded patients with untreated brain metastases; there have been no reports describing efficacy of sotorasib on untreated brain metastases. We present a case of a patient with active untreated brain metastases with resulting disorientation and weakness who has radiographic response and complete resolution of neurologic symptoms with sotorasib. Our case illustrates the intracranial activity of sotorasib, but additional studies are needed to characterize the intracranial response rate and duration of response in these patients.
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spelling pubmed-97190912022-12-04 Remarkable Intracranial Response to Sotorasib in a Patient With KRAS(G12C)-Mutated Lung Adenocarcinoma and Untreated Brain Metastases: A Case Report Yeh, Justin Marks, Jennifer A. Alzeer, Ali H. Sloan, Emily A. Varghese, Reshma Paudel, Nitika Reuss, Joshua E. Bergquist, Peter J. Liu, Stephen V. Kim, Chul JTO Clin Res Rep Case Report Sotorasib is a KRAS(G12C) inhibitor that recently received approval for use in locally advanced or metastatic KRAS(G12C)-mutated NSCLC. CodeBreaK100, the phase 2 clinical trial leading to the approval of sotorasib, excluded patients with untreated brain metastases; there have been no reports describing efficacy of sotorasib on untreated brain metastases. We present a case of a patient with active untreated brain metastases with resulting disorientation and weakness who has radiographic response and complete resolution of neurologic symptoms with sotorasib. Our case illustrates the intracranial activity of sotorasib, but additional studies are needed to characterize the intracranial response rate and duration of response in these patients. Elsevier 2022-11-06 /pmc/articles/PMC9719091/ /pubmed/36471683 http://dx.doi.org/10.1016/j.jtocrr.2022.100428 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yeh, Justin
Marks, Jennifer A.
Alzeer, Ali H.
Sloan, Emily A.
Varghese, Reshma
Paudel, Nitika
Reuss, Joshua E.
Bergquist, Peter J.
Liu, Stephen V.
Kim, Chul
Remarkable Intracranial Response to Sotorasib in a Patient With KRAS(G12C)-Mutated Lung Adenocarcinoma and Untreated Brain Metastases: A Case Report
title Remarkable Intracranial Response to Sotorasib in a Patient With KRAS(G12C)-Mutated Lung Adenocarcinoma and Untreated Brain Metastases: A Case Report
title_full Remarkable Intracranial Response to Sotorasib in a Patient With KRAS(G12C)-Mutated Lung Adenocarcinoma and Untreated Brain Metastases: A Case Report
title_fullStr Remarkable Intracranial Response to Sotorasib in a Patient With KRAS(G12C)-Mutated Lung Adenocarcinoma and Untreated Brain Metastases: A Case Report
title_full_unstemmed Remarkable Intracranial Response to Sotorasib in a Patient With KRAS(G12C)-Mutated Lung Adenocarcinoma and Untreated Brain Metastases: A Case Report
title_short Remarkable Intracranial Response to Sotorasib in a Patient With KRAS(G12C)-Mutated Lung Adenocarcinoma and Untreated Brain Metastases: A Case Report
title_sort remarkable intracranial response to sotorasib in a patient with kras(g12c)-mutated lung adenocarcinoma and untreated brain metastases: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719091/
https://www.ncbi.nlm.nih.gov/pubmed/36471683
http://dx.doi.org/10.1016/j.jtocrr.2022.100428
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