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BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1

Tumors with BRCA1 mutations have poor prognoses due to genomic instability. Yet this genomic instability has risks and BRCA1-deficient (def) cancer cells must develop pathways to mitigate these risks. One such risk is the accumulation of unfolded proteins in BRCA1-def cancers from increased mutation...

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Detalles Bibliográficos
Autores principales:	Hromas, Robert, Srinivasan, Gayathri, Yang, Ming, Jaiswal, Aruna, Totterdale, Taylor A., Phillips, Linda, Kirby, Austin, Khodayari, Nazli, Brantley, Mark, Williamson, Elizabeth A., Kong, Kimi Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719099/ https://www.ncbi.nlm.nih.gov/pubmed/36471805 http://dx.doi.org/10.1016/j.isci.2022.105626

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