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Enthesitis-related arthritis: the clinical characteristics and factors related to MRI remission of sacroiliitis

BACKGROUND: To describe the clinical characteristics and explore the factors related to the MRI remission of sacroiliitis in patients with enthesitis-related arthritis (ERA). METHODS: Patients with ERA from 2018–2022 in our medical center were retrospectively reviewed, which identified according to...

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Autores principales: Li, Jiaoyu, Zhu, Yaju, Guo, Guimei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719177/
https://www.ncbi.nlm.nih.gov/pubmed/36461063
http://dx.doi.org/10.1186/s12891-022-06028-8
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author Li, Jiaoyu
Zhu, Yaju
Guo, Guimei
author_facet Li, Jiaoyu
Zhu, Yaju
Guo, Guimei
author_sort Li, Jiaoyu
collection PubMed
description BACKGROUND: To describe the clinical characteristics and explore the factors related to the MRI remission of sacroiliitis in patients with enthesitis-related arthritis (ERA). METHODS: Patients with ERA from 2018–2022 in our medical center were retrospectively reviewed, which identified according to Pediatric Rheumatology International Trials Organization (PRINTO) criteria. Demographics, clinical characteristics, examinations, and treatments were described. Univariate and multivariate logistic regression models were used to analyze the factors related to MRI remission of sacroiliitis in ERA. RESULTS: This retrospective study included 160 ERA patients (51.9% male) with a mean onset age of 9.2 ± 3.0 years. There were 144 cases (81.9%) with peripheral arthritis, and the hip, knee, and ankle joints were the most commonly involved joints. Enthesitis occurred in 48 cases (30.0%), and sacroiliitis occurred in 142 cases (88.5%) at diagnosis. Human leukocyte antigen (HLA)-B27 was positive in 33 cases (17.1%), and acute uveitis occurred in 3 cases (1.9%). The majority of patients (93.7%) were treated with disease-modifying anti-rheumatic drugs (DMARDs), and 60% with biologics. Among 62 patients with MRI-defined sacroiliitis, 27 (43.5%) cases showed improvement in the sacroiliac joint lesion after treatment. Multivariate logistic regression analysis showed that duration from onset to diagnosis of less than 3 months (OR = 3.609, 95% CI: 1.068–12.192) and active joints of more than 4 (OR = 4.916, 95% CI: 1.006–24.037) were independent factors. CONCLUSION: We highlighted differences in ERA clinical characteristics. Patients with a shorter diagnosis time and more joint involvement improved more significantly in sacroiliac joint lesions after treatment.
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spelling pubmed-97191772022-12-04 Enthesitis-related arthritis: the clinical characteristics and factors related to MRI remission of sacroiliitis Li, Jiaoyu Zhu, Yaju Guo, Guimei BMC Musculoskelet Disord Research BACKGROUND: To describe the clinical characteristics and explore the factors related to the MRI remission of sacroiliitis in patients with enthesitis-related arthritis (ERA). METHODS: Patients with ERA from 2018–2022 in our medical center were retrospectively reviewed, which identified according to Pediatric Rheumatology International Trials Organization (PRINTO) criteria. Demographics, clinical characteristics, examinations, and treatments were described. Univariate and multivariate logistic regression models were used to analyze the factors related to MRI remission of sacroiliitis in ERA. RESULTS: This retrospective study included 160 ERA patients (51.9% male) with a mean onset age of 9.2 ± 3.0 years. There were 144 cases (81.9%) with peripheral arthritis, and the hip, knee, and ankle joints were the most commonly involved joints. Enthesitis occurred in 48 cases (30.0%), and sacroiliitis occurred in 142 cases (88.5%) at diagnosis. Human leukocyte antigen (HLA)-B27 was positive in 33 cases (17.1%), and acute uveitis occurred in 3 cases (1.9%). The majority of patients (93.7%) were treated with disease-modifying anti-rheumatic drugs (DMARDs), and 60% with biologics. Among 62 patients with MRI-defined sacroiliitis, 27 (43.5%) cases showed improvement in the sacroiliac joint lesion after treatment. Multivariate logistic regression analysis showed that duration from onset to diagnosis of less than 3 months (OR = 3.609, 95% CI: 1.068–12.192) and active joints of more than 4 (OR = 4.916, 95% CI: 1.006–24.037) were independent factors. CONCLUSION: We highlighted differences in ERA clinical characteristics. Patients with a shorter diagnosis time and more joint involvement improved more significantly in sacroiliac joint lesions after treatment. BioMed Central 2022-12-03 /pmc/articles/PMC9719177/ /pubmed/36461063 http://dx.doi.org/10.1186/s12891-022-06028-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Jiaoyu
Zhu, Yaju
Guo, Guimei
Enthesitis-related arthritis: the clinical characteristics and factors related to MRI remission of sacroiliitis
title Enthesitis-related arthritis: the clinical characteristics and factors related to MRI remission of sacroiliitis
title_full Enthesitis-related arthritis: the clinical characteristics and factors related to MRI remission of sacroiliitis
title_fullStr Enthesitis-related arthritis: the clinical characteristics and factors related to MRI remission of sacroiliitis
title_full_unstemmed Enthesitis-related arthritis: the clinical characteristics and factors related to MRI remission of sacroiliitis
title_short Enthesitis-related arthritis: the clinical characteristics and factors related to MRI remission of sacroiliitis
title_sort enthesitis-related arthritis: the clinical characteristics and factors related to mri remission of sacroiliitis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719177/
https://www.ncbi.nlm.nih.gov/pubmed/36461063
http://dx.doi.org/10.1186/s12891-022-06028-8
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