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ACT-26 PATTERN OF RECURRENCE IN NEWLY DIAGNOSED GLIOBLASTOMA TREATED WITH PHOTODYNAMIC THERAPY

In 2016, photodynamic therapy (PDT) system using talaporfin sodium was introduced to our hospital. By December 2021, we have experienced 22 cases (15 males, 7 females, 57.9±18.6 years old) of newly diagnosed glioblastoma (GBM) treated with PDT. The recurrence pattern of 22 cases was retrospectively...

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Autores principales: Nakayama, Noriyuki, Yamada, Tetsuya, Ohe, Naoyuki, Yano, Hirohito, Iwama, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719299/
http://dx.doi.org/10.1093/noajnl/vdac167.035
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author Nakayama, Noriyuki
Yamada, Tetsuya
Ohe, Naoyuki
Yano, Hirohito
Iwama, Toru
author_facet Nakayama, Noriyuki
Yamada, Tetsuya
Ohe, Naoyuki
Yano, Hirohito
Iwama, Toru
author_sort Nakayama, Noriyuki
collection PubMed
description In 2016, photodynamic therapy (PDT) system using talaporfin sodium was introduced to our hospital. By December 2021, we have experienced 22 cases (15 males, 7 females, 57.9±18.6 years old) of newly diagnosed glioblastoma (GBM) treated with PDT. The recurrence pattern of 22 cases was retrospectively examined. In August 2022, 7 cases are still alive. Laser irradiation was performed at an average of 7.6±3.4 sites. Tumor localization was solitary and superficial in 14 cases. Extent of tumor resection was 89.3±18.5%, and the postoperative KPS was 86.4±15.0%. Median PFS was 11 months, median OS was 18 months, and 5 patients survived for more than 3 years. Recurrences were observed in 16 cases, and the recurrence types were local (LR) in 9 cases, distant (DR) in 3 cases, and both in 4 cases. Two of the remaining 6 cases, which were judged to have no recurrence at present, had Gd-enhancing lesions locally and were judged to have LR. Therefore, re-resection was performed in both cases, but the pathological diagnosis was gliosis. Fujita et al. (J Neurooncol 155:81-92, 2021) reported that acute response of high-grade glioma to PDT can be detected as linear transient hyperintense signal (LTHS) on diffusion-weighted imaging (DWI), and that All of the LRs arose from areas that did not show LTHS on DWI obtained on day 1 after PDT. Furthermore, they reported that this characteristic finding is useful for monitoring LR after PDT. In our cases, 3 DRs and 4 existing long-term survivors (including 2 with local gliosis) showed nearly LTHS throughout the resected wall. On the other hand, partial absence of LTHS was confirmed in 13 cases containing LR. PDT provides effective local control, but it requires careful irradiation planning to avoid missing areas of irradiation, and LTHS on DWI could indicate whether effective irradiation has been achieved.
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spelling pubmed-97192992022-12-06 ACT-26 PATTERN OF RECURRENCE IN NEWLY DIAGNOSED GLIOBLASTOMA TREATED WITH PHOTODYNAMIC THERAPY Nakayama, Noriyuki Yamada, Tetsuya Ohe, Naoyuki Yano, Hirohito Iwama, Toru Neurooncol Adv Abstracts In 2016, photodynamic therapy (PDT) system using talaporfin sodium was introduced to our hospital. By December 2021, we have experienced 22 cases (15 males, 7 females, 57.9±18.6 years old) of newly diagnosed glioblastoma (GBM) treated with PDT. The recurrence pattern of 22 cases was retrospectively examined. In August 2022, 7 cases are still alive. Laser irradiation was performed at an average of 7.6±3.4 sites. Tumor localization was solitary and superficial in 14 cases. Extent of tumor resection was 89.3±18.5%, and the postoperative KPS was 86.4±15.0%. Median PFS was 11 months, median OS was 18 months, and 5 patients survived for more than 3 years. Recurrences were observed in 16 cases, and the recurrence types were local (LR) in 9 cases, distant (DR) in 3 cases, and both in 4 cases. Two of the remaining 6 cases, which were judged to have no recurrence at present, had Gd-enhancing lesions locally and were judged to have LR. Therefore, re-resection was performed in both cases, but the pathological diagnosis was gliosis. Fujita et al. (J Neurooncol 155:81-92, 2021) reported that acute response of high-grade glioma to PDT can be detected as linear transient hyperintense signal (LTHS) on diffusion-weighted imaging (DWI), and that All of the LRs arose from areas that did not show LTHS on DWI obtained on day 1 after PDT. Furthermore, they reported that this characteristic finding is useful for monitoring LR after PDT. In our cases, 3 DRs and 4 existing long-term survivors (including 2 with local gliosis) showed nearly LTHS throughout the resected wall. On the other hand, partial absence of LTHS was confirmed in 13 cases containing LR. PDT provides effective local control, but it requires careful irradiation planning to avoid missing areas of irradiation, and LTHS on DWI could indicate whether effective irradiation has been achieved. Oxford University Press 2022-12-03 /pmc/articles/PMC9719299/ http://dx.doi.org/10.1093/noajnl/vdac167.035 Text en © The Author(s) 2022. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Nakayama, Noriyuki
Yamada, Tetsuya
Ohe, Naoyuki
Yano, Hirohito
Iwama, Toru
ACT-26 PATTERN OF RECURRENCE IN NEWLY DIAGNOSED GLIOBLASTOMA TREATED WITH PHOTODYNAMIC THERAPY
title ACT-26 PATTERN OF RECURRENCE IN NEWLY DIAGNOSED GLIOBLASTOMA TREATED WITH PHOTODYNAMIC THERAPY
title_full ACT-26 PATTERN OF RECURRENCE IN NEWLY DIAGNOSED GLIOBLASTOMA TREATED WITH PHOTODYNAMIC THERAPY
title_fullStr ACT-26 PATTERN OF RECURRENCE IN NEWLY DIAGNOSED GLIOBLASTOMA TREATED WITH PHOTODYNAMIC THERAPY
title_full_unstemmed ACT-26 PATTERN OF RECURRENCE IN NEWLY DIAGNOSED GLIOBLASTOMA TREATED WITH PHOTODYNAMIC THERAPY
title_short ACT-26 PATTERN OF RECURRENCE IN NEWLY DIAGNOSED GLIOBLASTOMA TREATED WITH PHOTODYNAMIC THERAPY
title_sort act-26 pattern of recurrence in newly diagnosed glioblastoma treated with photodynamic therapy
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719299/
http://dx.doi.org/10.1093/noajnl/vdac167.035
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