PEDT-18 PHASE I/II TRIAL OF OP-10 (ONC201) IN JAPANESE PATIENTS WITH RELAPSED OR REFRACTORY DIFFUSE MIDLINE GLIOMA

BACKGROUND: Diffuse midline glioma (DMG) occurs mainly in the brain stem and most of patients have the mutation of histone (H3K27M). The prognosis is poor, and median overall survival (OS) is less than 12 months. OP-10 (ONC201) have antagonistic activity against dopamine D2 ha and to activate ClpP,...

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Detalles Bibliográficos
Autores principales: Okada, Keiko, Narita, Yoshitaka, Koga, Yuhki, Nishikawa, Ryo, Koh, Katsuyoshi, Manabe, Atsushi, Terashima, Keita, Miyairi, Kazunari, Taguchi, Fumi, Hara, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
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Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719357/
http://dx.doi.org/10.1093/noajnl/vdac167.040

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