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Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure
Premature ovarian failure (POF) is characterized by hormonal disorders, amenorrhea, and premature loss of fertility potential in women of reproductive age. Several studies have been conducted on the effectiveness of traditional Chinese medicine (TCM) in treating POF. TCM relied primarily on apoptosi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719426/ https://www.ncbi.nlm.nih.gov/pubmed/36471694 http://dx.doi.org/10.1155/2022/5413504 |
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author | Li, Ming Xiao, Yu-Bo Wei, Le Liu, Qi Liu, Pin-Yue Yao, Jian-Feng |
author_facet | Li, Ming Xiao, Yu-Bo Wei, Le Liu, Qi Liu, Pin-Yue Yao, Jian-Feng |
author_sort | Li, Ming |
collection | PubMed |
description | Premature ovarian failure (POF) is characterized by hormonal disorders, amenorrhea, and premature loss of fertility potential in women of reproductive age. Several studies have been conducted on the effectiveness of traditional Chinese medicine (TCM) in treating POF. TCM relied primarily on apoptosis, immunity, and aging to treat POF based on the studies of domestic and foreign literature. Zuogui pills inhibited mitochondrial-dependent apoptosis in the treatment of POF. Huyang Yangkun formula regulated the downstream of the Bcl-2 family to resist apoptosis through the aquaporin-1 protein. Modified Bazhen decoction regulated apoptosis in POF by regulating X-linked inhibitors of apoptosis protein. Bushen Tianjing recipe was effective in treating POF by promoting angiogenesis and preventing apoptosis. As for immunity, Bushen Jianpi prescription and Er-Xian decoction cured autoimmunity POF models and increased follicular development-related protein expression. Bushen Huoxue Tang improved ovarian function and reduced ovarian inflammation by regulating the Nrf2/Keap1 signaling pathway and T lymphocytes. Taohong Siwu decoction promoted the proliferation and differentiation of granulosa cells of POF mice by regulating the TGF-β1/Smads signaling pathway. In addition, ginsenoside Rg1 and Jiajian Guisheng formula treated POF by regulating cell aging-related mechanisms. Si Wu Tang treated POF by activating the angiogenesis-related proteins. The goal of this review is to serve as a reference for in-depth research into the treatment of POF with TCM and provide inspiration for new diagnostic methods and treatment options. |
format | Online Article Text |
id | pubmed-9719426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-97194262022-12-04 Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure Li, Ming Xiao, Yu-Bo Wei, Le Liu, Qi Liu, Pin-Yue Yao, Jian-Feng Evid Based Complement Alternat Med Review Article Premature ovarian failure (POF) is characterized by hormonal disorders, amenorrhea, and premature loss of fertility potential in women of reproductive age. Several studies have been conducted on the effectiveness of traditional Chinese medicine (TCM) in treating POF. TCM relied primarily on apoptosis, immunity, and aging to treat POF based on the studies of domestic and foreign literature. Zuogui pills inhibited mitochondrial-dependent apoptosis in the treatment of POF. Huyang Yangkun formula regulated the downstream of the Bcl-2 family to resist apoptosis through the aquaporin-1 protein. Modified Bazhen decoction regulated apoptosis in POF by regulating X-linked inhibitors of apoptosis protein. Bushen Tianjing recipe was effective in treating POF by promoting angiogenesis and preventing apoptosis. As for immunity, Bushen Jianpi prescription and Er-Xian decoction cured autoimmunity POF models and increased follicular development-related protein expression. Bushen Huoxue Tang improved ovarian function and reduced ovarian inflammation by regulating the Nrf2/Keap1 signaling pathway and T lymphocytes. Taohong Siwu decoction promoted the proliferation and differentiation of granulosa cells of POF mice by regulating the TGF-β1/Smads signaling pathway. In addition, ginsenoside Rg1 and Jiajian Guisheng formula treated POF by regulating cell aging-related mechanisms. Si Wu Tang treated POF by activating the angiogenesis-related proteins. The goal of this review is to serve as a reference for in-depth research into the treatment of POF with TCM and provide inspiration for new diagnostic methods and treatment options. Hindawi 2022-11-26 /pmc/articles/PMC9719426/ /pubmed/36471694 http://dx.doi.org/10.1155/2022/5413504 Text en Copyright © 2022 Ming Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Li, Ming Xiao, Yu-Bo Wei, Le Liu, Qi Liu, Pin-Yue Yao, Jian-Feng Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure |
title | Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure |
title_full | Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure |
title_fullStr | Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure |
title_full_unstemmed | Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure |
title_short | Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure |
title_sort | beneficial effects of traditional chinese medicine in the treatment of premature ovarian failure |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719426/ https://www.ncbi.nlm.nih.gov/pubmed/36471694 http://dx.doi.org/10.1155/2022/5413504 |
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