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Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity
Cerebellar learning is expressed as upbound or downbound changes in simple spike activity of Purkinje cell subpopulations, but the underlying mechanism remains enigmatic. By visualizing murine Purkinje cells with different molecular identities, we demonstrate that the potential for induction of long...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719509/ https://www.ncbi.nlm.nih.gov/pubmed/36463347 http://dx.doi.org/10.1038/s42003-022-04283-y |
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author | Voerman, Stijn Urbanus, Bastiaan H. A. Schonewille, Martijn White, Joshua J. De Zeeuw, Chris I. |
author_facet | Voerman, Stijn Urbanus, Bastiaan H. A. Schonewille, Martijn White, Joshua J. De Zeeuw, Chris I. |
author_sort | Voerman, Stijn |
collection | PubMed |
description | Cerebellar learning is expressed as upbound or downbound changes in simple spike activity of Purkinje cell subpopulations, but the underlying mechanism remains enigmatic. By visualizing murine Purkinje cells with different molecular identities, we demonstrate that the potential for induction of long-term depression is prominent in downbound and minimal in the upbound subpopulation. These differential propensities depend on the expression profile, but not on the synaptic inputs, of the individual Purkinje cell involved, highlighting the functional relevance of intrinsic properties for memory formation. |
format | Online Article Text |
id | pubmed-9719509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97195092022-12-05 Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity Voerman, Stijn Urbanus, Bastiaan H. A. Schonewille, Martijn White, Joshua J. De Zeeuw, Chris I. Commun Biol Article Cerebellar learning is expressed as upbound or downbound changes in simple spike activity of Purkinje cell subpopulations, but the underlying mechanism remains enigmatic. By visualizing murine Purkinje cells with different molecular identities, we demonstrate that the potential for induction of long-term depression is prominent in downbound and minimal in the upbound subpopulation. These differential propensities depend on the expression profile, but not on the synaptic inputs, of the individual Purkinje cell involved, highlighting the functional relevance of intrinsic properties for memory formation. Nature Publishing Group UK 2022-12-03 /pmc/articles/PMC9719509/ /pubmed/36463347 http://dx.doi.org/10.1038/s42003-022-04283-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Voerman, Stijn Urbanus, Bastiaan H. A. Schonewille, Martijn White, Joshua J. De Zeeuw, Chris I. Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity |
title | Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity |
title_full | Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity |
title_fullStr | Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity |
title_full_unstemmed | Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity |
title_short | Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity |
title_sort | postsynaptic plasticity of purkinje cells in mice is determined by molecular identity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719509/ https://www.ncbi.nlm.nih.gov/pubmed/36463347 http://dx.doi.org/10.1038/s42003-022-04283-y |
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