A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA

Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide clinical precision oncology. Here we develop Griffin, a framework for profiling nucleosome protection and accessibility from cfDNA to study the phenotype of tumors using as low as 0.1x coverage whole genome...

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Detalles Bibliográficos
Autores principales: Doebley, Anna-Lisa, Ko, Minjeong, Liao, Hanna, Cruikshank, A. Eden, Santos, Katheryn, Kikawa, Caroline, Hiatt, Joseph B., Patton, Robert D., De Sarkar, Navonil, Collier, Katharine A., Hoge, Anna C. H., Chen, Katharine, Zimmer, Anat, Weber, Zachary T., Adil, Mohamed, Reichel, Jonathan B., Polak, Paz, Adalsteinsson, Viktor A., Nelson, Peter S., MacPherson, David, Parsons, Heather A., Stover, Daniel G., Ha, Gavin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719521/
https://www.ncbi.nlm.nih.gov/pubmed/36463275
http://dx.doi.org/10.1038/s41467-022-35076-w

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