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Synthesis of an amphiphilic vancomycin aglycone derivative inspired by polymyxins: overcoming glycopeptide resistance in Gram-positive and Gram-negative bacteria in synergy with teicoplanin in vitro

Gram-negative bacteria possess intrinsic resistance to glycopeptide antibiotics so these important antibacterial medications are only suitable for the treatment of Gram-positive bacterial infections. At the same time, polymyxins are peptide antibiotics, structurally related to glycopeptides, with re...

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Detalles Bibliográficos
Autores principales:	Szűcs, Zsolt, Bereczki, Ilona, Fenyvesi, Ferenc, Herczegh, Pál, Ostorházi, Eszter, Borbás, Anikó
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719540/ https://www.ncbi.nlm.nih.gov/pubmed/36463278 http://dx.doi.org/10.1038/s41598-022-24807-0

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