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Three-dimensional close-to-substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes
The transport of magnetic particles (MPs) by dynamic magnetic field landscapes (MFLs) using magnetically patterned substrates is promising for the development of Lab-on-a-chip (LOC) systems. The inherent close-to-substrate MP motion is sensitive to changing particle–substrate interactions. Thus, the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719552/ https://www.ncbi.nlm.nih.gov/pubmed/36463293 http://dx.doi.org/10.1038/s41598-022-25391-z |
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author | Huhnstock, Rico Reginka, Meike Sonntag, Claudius Merkel, Maximilian Dingel, Kristina Sick, Bernhard Vogel, Michael Ehresmann, Arno |
author_facet | Huhnstock, Rico Reginka, Meike Sonntag, Claudius Merkel, Maximilian Dingel, Kristina Sick, Bernhard Vogel, Michael Ehresmann, Arno |
author_sort | Huhnstock, Rico |
collection | PubMed |
description | The transport of magnetic particles (MPs) by dynamic magnetic field landscapes (MFLs) using magnetically patterned substrates is promising for the development of Lab-on-a-chip (LOC) systems. The inherent close-to-substrate MP motion is sensitive to changing particle–substrate interactions. Thus, the detection of a modified particle–substrate separation distance caused by surface binding of an analyte is expected to be a promising probe in analytics and diagnostics. Here, we present an essential prerequisite for such an application, namely the label-free quantitative experimental determination of the three-dimensional trajectories of superparamagnetic particles (SPPs) transported by a dynamically changing MFL. The evaluation of defocused SPP images from optical bright-field microscopy revealed a “hopping”-like motion of the magnetic particles, previously predicted by theory, additionally allowing a quantification of maximum jump heights. As our findings pave the way towards precise determination of particle–substrate separations, they bear deep implications for future LOC detection schemes using only optical microscopy. |
format | Online Article Text |
id | pubmed-9719552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97195522022-12-05 Three-dimensional close-to-substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes Huhnstock, Rico Reginka, Meike Sonntag, Claudius Merkel, Maximilian Dingel, Kristina Sick, Bernhard Vogel, Michael Ehresmann, Arno Sci Rep Article The transport of magnetic particles (MPs) by dynamic magnetic field landscapes (MFLs) using magnetically patterned substrates is promising for the development of Lab-on-a-chip (LOC) systems. The inherent close-to-substrate MP motion is sensitive to changing particle–substrate interactions. Thus, the detection of a modified particle–substrate separation distance caused by surface binding of an analyte is expected to be a promising probe in analytics and diagnostics. Here, we present an essential prerequisite for such an application, namely the label-free quantitative experimental determination of the three-dimensional trajectories of superparamagnetic particles (SPPs) transported by a dynamically changing MFL. The evaluation of defocused SPP images from optical bright-field microscopy revealed a “hopping”-like motion of the magnetic particles, previously predicted by theory, additionally allowing a quantification of maximum jump heights. As our findings pave the way towards precise determination of particle–substrate separations, they bear deep implications for future LOC detection schemes using only optical microscopy. Nature Publishing Group UK 2022-12-03 /pmc/articles/PMC9719552/ /pubmed/36463293 http://dx.doi.org/10.1038/s41598-022-25391-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Huhnstock, Rico Reginka, Meike Sonntag, Claudius Merkel, Maximilian Dingel, Kristina Sick, Bernhard Vogel, Michael Ehresmann, Arno Three-dimensional close-to-substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes |
title | Three-dimensional close-to-substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes |
title_full | Three-dimensional close-to-substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes |
title_fullStr | Three-dimensional close-to-substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes |
title_full_unstemmed | Three-dimensional close-to-substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes |
title_short | Three-dimensional close-to-substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes |
title_sort | three-dimensional close-to-substrate trajectories of magnetic microparticles in dynamically changing magnetic field landscapes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719552/ https://www.ncbi.nlm.nih.gov/pubmed/36463293 http://dx.doi.org/10.1038/s41598-022-25391-z |
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