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Immune response and homeostasis mechanism following administration of BBIBP-CorV SARS-CoV-2 inactivated vaccine

The BBIBP-CorV severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivated vaccine has been authorized for emergency use and widely distributed. We used single-cell transcriptome sequencing to characterize the dynamics of immune responses to the BBIBP-CorV inactivated vaccine. In additi...

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Detalles Bibliográficos
Autores principales: Yin, Jianhua, Zhao, Yingze, Huang, Fubaoqian, Yang, Yunkai, Huang, Yaling, Zhuang, Zhenkun, Wang, Yanxia, Wang, Zhifeng, Lin, Xiumei, Zheng, Yuhui, Zhou, Wenwen, Wang, Shuo, Xu, Ziqian, Ye, Beiwei, Guo, Yaxin, Lei, Wenwen, Li, Lei, Tian, Jinmin, Gan, Jinxian, Wang, Hui, Wang, Wei, Ma, Peiyao, Liu, Chang, Wei, Xiaoyu, Shi, Xuyang, Wang, Zifei, Wang, Yang, Liu, Ying, Yang, Mingming, Yuan, Yue, Song, Yumo, Ma, Wen, Huang, Zhuoli, Liu, Ya, Huang, Yunting, Lu, Haorong, Liu, Peipei, Liang, Hao, Hou, Yong, Xu, Xun, Liu, Longqi, Zhang, Yuntao, Wu, Guizhen, Gao, George F., Jin, Xin, Liu, Chuanyu, Yang, Xiaoming, Liu, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719934/
https://www.ncbi.nlm.nih.gov/pubmed/36506806
http://dx.doi.org/10.1016/j.xinn.2022.100359
Descripción
Sumario:The BBIBP-CorV severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivated vaccine has been authorized for emergency use and widely distributed. We used single-cell transcriptome sequencing to characterize the dynamics of immune responses to the BBIBP-CorV inactivated vaccine. In addition to the expected induction of humoral immunity, we found that the inactivated vaccine induced multiple, comprehensive immune responses, including significantly increased proportions of CD16(+) monocytes and activation of monocyte antigen presentation pathways; T cell activation pathway upregulation in CD8(+) T cells, along with increased activation of CD4(+) T cells; significant enhancement of cell-cell communications between innate and adaptive immunity; and the induction of regulatory CD4(+) T cells and co-inhibitory interactions to maintain immune homeostasis after vaccination. Additionally, comparative analysis revealed higher neutralizing antibody levels, distinct expansion of naive T cells, a shared increased proportion of regulatory CD4(+) T cells, and upregulated expression of functional genes in booster dose recipients with a longer interval after the second vaccination. Our research will support a comprehensive understanding of the systemic immune responses elicited by the BBIBP-CorV inactivated vaccine, which will facilitate the formulation of better vaccination strategies and the design of new vaccines.