c-Kit M541L variant is related to ineffective hemopoiesis predisposing to clonal evolution in 3D in vitro biomimetic co-culture model of bone marrow niche

Hematopoietic stem cell (HSC) maintenance in vitro is challenging because stem cell survival relies on cell-to-cell contacts and paracrine signals from bone marrow (BM) microenvironment. Indeed, HSCs easily differentiate in conventional culture systems, and in vitro study of stem cell biology, leuke...

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Detalles Bibliográficos
Autores principales: Manzo, Paola, Scala, Pasqualina, Giudice, Valentina, Gorrese, Marisa, Bertolini, Angela, Morini, Denise, D'Alto, Francesca, Pepe, Rita, Pedicini, Antonio, Izzo, Barbara, Verdesca, Francesco, Langella, Maddalena, Serio, Bianca, Della Porta, Giovanna, Selleri, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720035/
https://www.ncbi.nlm.nih.gov/pubmed/36478848
http://dx.doi.org/10.1016/j.heliyon.2022.e11998

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