Design and characterization of a heterobifunctional degrader of KEAP1

The Kelch-like ECH-associated protein 1 (KEAP1) - nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway senses reactive oxygen species and regulates cellular oxidative stress. Inhibiting KEAP1 to activate the NRF2 antioxidant response has been proposed as a promising strategy to treat...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Nguyen, Nghi H., Magtoto, Charlene M., Cobbold, Simon A., Bidgood, Grace M., Meza Guzman, Lizeth G., Richardson, Lachlan W., Corbin, Jason, Au, Amanda E., Lechtenberg, Bernhard C., Feltham, Rebecca, Sutherland, Kate D., Grohmann, Christoph, Nicholson, Sandra E., Sleebs, Brad E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720105/
https://www.ncbi.nlm.nih.gov/pubmed/36473314
http://dx.doi.org/10.1016/j.redox.2022.102552

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