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Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus 1

G-quadruplexes (G4s) are non-canonical nucleic acid structures that regulate key biological processes, from transcription to genome replication both in humans and viruses. The herpes simplex virus-1 (HSV-1) genome is prone to form G4s that, along with proteins, regulate its viral cycle. General G4 l...

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Detalles Bibliográficos
Autores principales:	Frasson, Ilaria, Soldà, Paola, Nadai, Matteo, Tassinari, Martina, Scalabrin, Matteo, Gokhale, Vijay, Hurley, Laurence H., Richter, Sara N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720158/ https://www.ncbi.nlm.nih.gov/pubmed/36228762 http://dx.doi.org/10.1016/j.antiviral.2022.105432

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