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Further validation of the THINC‐it tool and extension of the normative data set in a study of n = 10.019 typical controls

INTRODUCTION: We report further validation and normative data for the THINC‐Integrated Tool (THINC‐it), a measure of cognitive function designed for use with individuals living with Major Depressive Disorder, but which is finding use in further psychiatric and neurological diseases. THINC‐it compris...

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Autores principales: Dalby, Maria, Annas, Peter, Harrison, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720188/
https://www.ncbi.nlm.nih.gov/pubmed/35748111
http://dx.doi.org/10.1002/mpr.1922
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author Dalby, Maria
Annas, Peter
Harrison, John E.
author_facet Dalby, Maria
Annas, Peter
Harrison, John E.
author_sort Dalby, Maria
collection PubMed
description INTRODUCTION: We report further validation and normative data for the THINC‐Integrated Tool (THINC‐it), a measure of cognitive function designed for use with individuals living with Major Depressive Disorder, but which is finding use in further psychiatric and neurological diseases. THINC‐it comprises four objective computerised cognitive tests based on traditional psychological paradigms and a version of the Perceived Deficits Questionnaire assessment. METHODS: Sample size of n = 10.019 typical control study participants were tested on one to two occasions to further validate the reliability of THINC‐it. Temporal reliability was assessed across 120–180 days. RESULTS: Test‐retest reliability correlations varied between r = 0.50 and 0.72 for the component measures and r = 0.75 (95% confidence intervals 0.74, 0.76) for the THINC‐it composite score. Normative data categorised by Age, Sex and Years of Education were calculated and the effect on task performance was reported. DISCUSSION: Our analysis confirms previously reported levels of reliability and validates previously reported normative data values.
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spelling pubmed-97201882022-12-06 Further validation of the THINC‐it tool and extension of the normative data set in a study of n = 10.019 typical controls Dalby, Maria Annas, Peter Harrison, John E. Int J Methods Psychiatr Res Original Articles INTRODUCTION: We report further validation and normative data for the THINC‐Integrated Tool (THINC‐it), a measure of cognitive function designed for use with individuals living with Major Depressive Disorder, but which is finding use in further psychiatric and neurological diseases. THINC‐it comprises four objective computerised cognitive tests based on traditional psychological paradigms and a version of the Perceived Deficits Questionnaire assessment. METHODS: Sample size of n = 10.019 typical control study participants were tested on one to two occasions to further validate the reliability of THINC‐it. Temporal reliability was assessed across 120–180 days. RESULTS: Test‐retest reliability correlations varied between r = 0.50 and 0.72 for the component measures and r = 0.75 (95% confidence intervals 0.74, 0.76) for the THINC‐it composite score. Normative data categorised by Age, Sex and Years of Education were calculated and the effect on task performance was reported. DISCUSSION: Our analysis confirms previously reported levels of reliability and validates previously reported normative data values. John Wiley and Sons Inc. 2022-06-24 /pmc/articles/PMC9720188/ /pubmed/35748111 http://dx.doi.org/10.1002/mpr.1922 Text en © 2022 The Authors. International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Dalby, Maria
Annas, Peter
Harrison, John E.
Further validation of the THINC‐it tool and extension of the normative data set in a study of n = 10.019 typical controls
title Further validation of the THINC‐it tool and extension of the normative data set in a study of n = 10.019 typical controls
title_full Further validation of the THINC‐it tool and extension of the normative data set in a study of n = 10.019 typical controls
title_fullStr Further validation of the THINC‐it tool and extension of the normative data set in a study of n = 10.019 typical controls
title_full_unstemmed Further validation of the THINC‐it tool and extension of the normative data set in a study of n = 10.019 typical controls
title_short Further validation of the THINC‐it tool and extension of the normative data set in a study of n = 10.019 typical controls
title_sort further validation of the thinc‐it tool and extension of the normative data set in a study of n = 10.019 typical controls
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720188/
https://www.ncbi.nlm.nih.gov/pubmed/35748111
http://dx.doi.org/10.1002/mpr.1922
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