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Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors

BACKGROUND: Chimeric antigen receptor T (CAR-T) cell therapy has made significant advances for hematological malignancies but encounters obstacles in the treatment of solid tumors mainly due to tumor immunosuppressive microenvironment. METHODS: Immunohistochemistry analysis was performed to examine...

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Detalles Bibliográficos
Autores principales:	Li, Fanfan, Zhao, Shuping, Wei, Cheng, Hu, Yaodi, Xu, Tianlong, Xin, Xueyi, Zhu, Tingwei, Shang, Liting, Ke, Shanwen, Zhou, Jiang, Xu, Xiaojun, Gao, Yue, Zhao, Ai, Gao, Jimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720259/ https://www.ncbi.nlm.nih.gov/pubmed/36479116 http://dx.doi.org/10.3389/fimmu.2022.958082

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