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A comprehensive prognostic and immune infiltration analysis of EXOC3L1 in pan-cancer

Exocyst complex component 3 like 1 (EXOC3L1) is widely present in various human tissues, which mainly regulates insulin secretion. However, its roles in tumors remain unclear. In the present study, we aimed to investigate the roles of EXOC3L1 in pan-cancer, and the data was downloaded from of the Un...

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Autor principal: Zhang, Zhan-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720260/
https://www.ncbi.nlm.nih.gov/pubmed/36479245
http://dx.doi.org/10.3389/fgene.2022.1044100
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author Zhang, Zhan-Fei
author_facet Zhang, Zhan-Fei
author_sort Zhang, Zhan-Fei
collection PubMed
description Exocyst complex component 3 like 1 (EXOC3L1) is widely present in various human tissues, which mainly regulates insulin secretion. However, its roles in tumors remain unclear. In the present study, we aimed to investigate the roles of EXOC3L1 in pan-cancer, and the data was downloaded from of the University of California Santa Cruz (UCSC) Xena and the Cancer Genome Atlas (TCGA). The expression status of EXOC3L1 was studied in the TCGA_GTEx samples, TCGA samples and paired samples in TCGA, respectively. Subsequently, Kaplan-Meier analysis was applied to 33 kinds of tumors in TCGA, among the cancers that EXOC3L1 can affect prognosis, clinical correlation analysis and univariate Cox regression analysis were performed. Furthermore, representative cancers kidney renal clear cell carcinoma (KIRC) and lung squamous cell carcinoma (LUSC) with a sample size larger than 500 were selected to construct nomogram models to confirm the prognostic value of EXOC3L1 in cancers. Additionally, the associations of EXOC3L1 with immune cell infiltrations were performed as well. Mechanistically, functional enrichment analysis was performed to explore potential signaling pathways that EXOC3L1 may involve in. Our study found that EXOC3L1 was differentially expressed in a variety of tumors and was associated with the clinical outcomes and immune microenvironment of several tumors, it may affect the occurrence and development of tumors through NOTCH signaling pathway, PI3K-AKT signaling pathway and immune-related pathways. In conclusion, we propose that EXOC3L1 may serve as a potential prognostic biomarker and a promising target for cancer immunotherapy in a variety of cancers.
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spelling pubmed-97202602022-12-06 A comprehensive prognostic and immune infiltration analysis of EXOC3L1 in pan-cancer Zhang, Zhan-Fei Front Genet Genetics Exocyst complex component 3 like 1 (EXOC3L1) is widely present in various human tissues, which mainly regulates insulin secretion. However, its roles in tumors remain unclear. In the present study, we aimed to investigate the roles of EXOC3L1 in pan-cancer, and the data was downloaded from of the University of California Santa Cruz (UCSC) Xena and the Cancer Genome Atlas (TCGA). The expression status of EXOC3L1 was studied in the TCGA_GTEx samples, TCGA samples and paired samples in TCGA, respectively. Subsequently, Kaplan-Meier analysis was applied to 33 kinds of tumors in TCGA, among the cancers that EXOC3L1 can affect prognosis, clinical correlation analysis and univariate Cox regression analysis were performed. Furthermore, representative cancers kidney renal clear cell carcinoma (KIRC) and lung squamous cell carcinoma (LUSC) with a sample size larger than 500 were selected to construct nomogram models to confirm the prognostic value of EXOC3L1 in cancers. Additionally, the associations of EXOC3L1 with immune cell infiltrations were performed as well. Mechanistically, functional enrichment analysis was performed to explore potential signaling pathways that EXOC3L1 may involve in. Our study found that EXOC3L1 was differentially expressed in a variety of tumors and was associated with the clinical outcomes and immune microenvironment of several tumors, it may affect the occurrence and development of tumors through NOTCH signaling pathway, PI3K-AKT signaling pathway and immune-related pathways. In conclusion, we propose that EXOC3L1 may serve as a potential prognostic biomarker and a promising target for cancer immunotherapy in a variety of cancers. Frontiers Media S.A. 2022-11-21 /pmc/articles/PMC9720260/ /pubmed/36479245 http://dx.doi.org/10.3389/fgene.2022.1044100 Text en Copyright © 2022 Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Zhang, Zhan-Fei
A comprehensive prognostic and immune infiltration analysis of EXOC3L1 in pan-cancer
title A comprehensive prognostic and immune infiltration analysis of EXOC3L1 in pan-cancer
title_full A comprehensive prognostic and immune infiltration analysis of EXOC3L1 in pan-cancer
title_fullStr A comprehensive prognostic and immune infiltration analysis of EXOC3L1 in pan-cancer
title_full_unstemmed A comprehensive prognostic and immune infiltration analysis of EXOC3L1 in pan-cancer
title_short A comprehensive prognostic and immune infiltration analysis of EXOC3L1 in pan-cancer
title_sort comprehensive prognostic and immune infiltration analysis of exoc3l1 in pan-cancer
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720260/
https://www.ncbi.nlm.nih.gov/pubmed/36479245
http://dx.doi.org/10.3389/fgene.2022.1044100
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