Divergent roles of PD-L1 in immune regulation during ischemia–reperfusion injury

Ischemia–reperfusion (I/R) injury is a type of pathological injury that commonly arises in various diseases. Various forms of immune response are involved in the process of I/R injury. As a member of the B7 costimulatory molecule family, programmed death 1-ligand 1 (PD-L1) is an important target for...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Jianheng, Liu, Ke, Wang, Yong, Li, Hongge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720307/
https://www.ncbi.nlm.nih.gov/pubmed/36479124
http://dx.doi.org/10.3389/fimmu.2022.1021452
_version_ 1784843527452098560
author Luo, Jianheng
Liu, Ke
Wang, Yong
Li, Hongge
author_facet Luo, Jianheng
Liu, Ke
Wang, Yong
Li, Hongge
author_sort Luo, Jianheng
collection PubMed
description Ischemia–reperfusion (I/R) injury is a type of pathological injury that commonly arises in various diseases. Various forms of immune response are involved in the process of I/R injury. As a member of the B7 costimulatory molecule family, programmed death 1-ligand 1 (PD-L1) is an important target for immune regulation. Therefore, PD-L1 may be implicated in the regulation of I/R injury. This review briefly describes the immune response during I/R injury and how PD-L1 is involved in its regulation by focusing on findings from various I/R models. Despite the limited number of studies in this field of research, PD-L1 has shown sufficient potential as a clinical therapeutic target.
format Online
Article
Text
id pubmed-9720307
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97203072022-12-06 Divergent roles of PD-L1 in immune regulation during ischemia–reperfusion injury Luo, Jianheng Liu, Ke Wang, Yong Li, Hongge Front Immunol Immunology Ischemia–reperfusion (I/R) injury is a type of pathological injury that commonly arises in various diseases. Various forms of immune response are involved in the process of I/R injury. As a member of the B7 costimulatory molecule family, programmed death 1-ligand 1 (PD-L1) is an important target for immune regulation. Therefore, PD-L1 may be implicated in the regulation of I/R injury. This review briefly describes the immune response during I/R injury and how PD-L1 is involved in its regulation by focusing on findings from various I/R models. Despite the limited number of studies in this field of research, PD-L1 has shown sufficient potential as a clinical therapeutic target. Frontiers Media S.A. 2022-11-21 /pmc/articles/PMC9720307/ /pubmed/36479124 http://dx.doi.org/10.3389/fimmu.2022.1021452 Text en Copyright © 2022 Luo, Liu, Wang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Luo, Jianheng
Liu, Ke
Wang, Yong
Li, Hongge
Divergent roles of PD-L1 in immune regulation during ischemia–reperfusion injury
title Divergent roles of PD-L1 in immune regulation during ischemia–reperfusion injury
title_full Divergent roles of PD-L1 in immune regulation during ischemia–reperfusion injury
title_fullStr Divergent roles of PD-L1 in immune regulation during ischemia–reperfusion injury
title_full_unstemmed Divergent roles of PD-L1 in immune regulation during ischemia–reperfusion injury
title_short Divergent roles of PD-L1 in immune regulation during ischemia–reperfusion injury
title_sort divergent roles of pd-l1 in immune regulation during ischemia–reperfusion injury
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720307/
https://www.ncbi.nlm.nih.gov/pubmed/36479124
http://dx.doi.org/10.3389/fimmu.2022.1021452
work_keys_str_mv AT luojianheng divergentrolesofpdl1inimmuneregulationduringischemiareperfusioninjury
AT liuke divergentrolesofpdl1inimmuneregulationduringischemiareperfusioninjury
AT wangyong divergentrolesofpdl1inimmuneregulationduringischemiareperfusioninjury
AT lihongge divergentrolesofpdl1inimmuneregulationduringischemiareperfusioninjury

Ejemplares similares