Triatoma costalimai, a neglected vector of Trypanosoma cruzi in the Cerrado savannas of South America: A comprehensive review

Triatoma costalimai is a little-known triatomine-bug species whose role as a vector of Chagas disease remains poorly understood. To address this gap, we conducted a comprehensive review of the literature and assessed the evidence base from a public-health perspective. We found 89 individual documents/resources with information about T. costalimai. DNA-sequence and cytogenetic data indicate that T. costalimai belongs, together with Triatoma jatai, in a distinct clade within the ‘pseudomaculata group’ of South American Triatoma. Triatoma costalimai is probably a narrow endemic of the Cerrado on the upper Tocantins River Basin and associated ranges/plateaus; there, the species thrives in the sandstone/limestone outcrops typical of the “Cerrado rupestre” (rocky-soil savanna) and “mata seca decídua calcária” (limestone-soil dry forest) phytophysiognomies. Wild T. costalimai appear to feed on whatever vertebrates are available in rocky outcrops, with lizards and rodents being most common. There is persuasive evidence that house invasion/infestation by T. costalimai has increased in frequency since the 1990s. The bugs often carry Trypanosoma cruzi, often defecate while feeding, have high fecundity/fertility, and, under overtly favorable conditions, can produce two generations per year. Current knowledge suggests that T. costalimai can transmit human Chagas disease in the upper Tocantins Basin; control-surveillance systems should ‘tag’ the species as a potentially important local vector in the Brazilian states of Goiás and Tocantins. Further research is needed to clarify (i) the drivers and dynamics of house invasion, infestation, and reinfestation by T. costalimai and (ii) the genetic structuring and vector capacity of the species, including its wild and non-wild populations.