Binding characterization of anthraquinone derivatives by stabilizing G-quadruplex DNA leads to an anticancerous activity

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G-quadruplex is a non-canonical secondary structure identified in the telomeric region and the promoter of many oncogenes. Anthraquinone derivatives, a well-known inducer of telomere disruption in malignant cells and activate the apoptotic pathway. We used biophysical and biochemical studies to conf...

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Detalles Bibliográficos
Autores principales: Dey, Arpita, Pandav, Kumud, Nath, Mala, Barthwal, Ritu, Prasad, Ramasare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720492/
https://www.ncbi.nlm.nih.gov/pubmed/36514353
http://dx.doi.org/10.1016/j.omtn.2022.11.008

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