Macromolecular crowding amplifies allosteric regulation of T-cell protein tyrosine phosphatase

T-cell protein tyrosine phosphatase (TC-PTP) is a negative regulator of T-cell receptor and oncogenic receptor tyrosine kinase signaling and implicated in cancer and autoimmune disease. TC-PTP activity is modulated by an intrinsically disordered C-terminal region (IDR) and suppressed in cells under...

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Detalles Bibliográficos
Autores principales: Tun, May Thwe, Yang, Shen, Forti, Fabio Luis, Santelli, Eugenio, Bottini, Nunzio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720572/
https://www.ncbi.nlm.nih.gov/pubmed/36328244
http://dx.doi.org/10.1016/j.jbc.2022.102655

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