Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

BACKGROUND: Aggregation of the amyloid-β (Aβ) peptide in the brain is one of the key pathological events in Alzheimer’s disease (AD). Reducing Aβ levels in the brain by enhancing its degradation is one possible strategy to develop new therapies for AD. Neprilysin (NEP) is a membrane-bound metallopep...

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Detalles Bibliográficos
Autores principales: Rofo, Fadi, Metzendorf, Nicole G., Saubi, Cristina, Suominen, Laura, Godec, Ana, Sehlin, Dag, Syvänen, Stina, Hultqvist, Greta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720954/
https://www.ncbi.nlm.nih.gov/pubmed/36471433
http://dx.doi.org/10.1186/s13195-022-01132-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720954/
https://www.ncbi.nlm.nih.gov/pubmed/36471433
http://dx.doi.org/10.1186/s13195-022-01132-2

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