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A novel Bayesian adaptive design incorporating both primary and secondary endpoints for randomized IIB chemoprevention study of women at increased risk for breast cancer

BACKGROUND: Our randomized controlled clinical trial will explore the potential of bazedoxifene plus conjugated estrogen to modulate breast tissue-based risk biomarkers as a surrogate for breast cancer risk reduction. This paper investigates the statistical design features of the trial and the ratio...

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Detalles Bibliográficos
Autores principales:	Gajewski, Byron J., Kimler, Bruce F., Koestler, Devin C., Mudaranthakam, Dinesh Pal, Young, Kate, Fabian, Carol J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721008/ https://www.ncbi.nlm.nih.gov/pubmed/36471449 http://dx.doi.org/10.1186/s13063-022-06930-5

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