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Similarities between maternal and fetal RR interval tachograms and their association with fetal development

An association between maternal and fetal heart rate (HR) has been reported but, so far, little is known about its physiological implication and importance relative to fetal development. Associations between both HRs were investigated previously by performing beat-by-beat coupling analysis and corre...

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Autores principales: Widatalla, Namareq, Khandoker, Ahsan, Alkhodari, Mohanad, Koide, Kunihiro, Yoshida, Chihiro, Kasahara, Yoshiyuki, Kimura, Yoshitaka, Saito, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721082/
https://www.ncbi.nlm.nih.gov/pubmed/36479345
http://dx.doi.org/10.3389/fphys.2022.964755
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author Widatalla, Namareq
Khandoker, Ahsan
Alkhodari, Mohanad
Koide, Kunihiro
Yoshida, Chihiro
Kasahara, Yoshiyuki
Kimura, Yoshitaka
Saito, Masatoshi
author_facet Widatalla, Namareq
Khandoker, Ahsan
Alkhodari, Mohanad
Koide, Kunihiro
Yoshida, Chihiro
Kasahara, Yoshiyuki
Kimura, Yoshitaka
Saito, Masatoshi
author_sort Widatalla, Namareq
collection PubMed
description An association between maternal and fetal heart rate (HR) has been reported but, so far, little is known about its physiological implication and importance relative to fetal development. Associations between both HRs were investigated previously by performing beat-by-beat coupling analysis and correlation analysis between average maternal and fetal HRs. However, studies reporting on the presence of similarities between maternal and fetal HRs or RR intervals (RRIs) over the short term (e.g., 5-min) at different gestational ages (GAs) are scarce. Here, we demonstrate the presence of similarities in the variations exhibited by maternal and fetal RRl tachograms (RRITs). To quantify the same similarities, a cross-correlation (CC) analysis between resampled maternal and fetal RRITs was conducted; RRITs were obtained from non-invasive electrocardiogram (ECG). The degree of similarity between maternal and fetal RRITs (bmfRRITs) was quantified by calculating four CC coefficients. CC analysis was performed for a total of 330 segments (two 5-min segments from 158 subjects and one 5-min from 14 subjects). To investigate the association of the similarity bmfRRITs with fetal development, the linear correlation between the calculated CC coefficients and GA was calculated. The results from the latter analysis showed that similarities bmfRRITs are common occurrences, they can be negative or positive, and they increase with GA suggesting the presence of a regulation that is associated with proper fetal development. To get an insight into the physiological mechanisms involved in the similarity bmfRRITs, the association of the same similarity with maternal and fetal HR variability (HRV) was investigated by comparing the means of two groups in which one of them had higher CC values compared to the other. The two groups were created by using the data from the 158 subjects where fetal RRI (fRRI) calculation from two 5-min ECG segments was feasible. The results of the comparison showed that the maternal very low frequency (VLF) HRV parameter is potentially associated with the similarity bmfRRITs implying that maternal hormones could be linked to the regulations involved in the similarity bmfRRITs. Our findings in this study reinforce the role of the maternal intrauterine environment on fetal development.
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spelling pubmed-97210822022-12-06 Similarities between maternal and fetal RR interval tachograms and their association with fetal development Widatalla, Namareq Khandoker, Ahsan Alkhodari, Mohanad Koide, Kunihiro Yoshida, Chihiro Kasahara, Yoshiyuki Kimura, Yoshitaka Saito, Masatoshi Front Physiol Physiology An association between maternal and fetal heart rate (HR) has been reported but, so far, little is known about its physiological implication and importance relative to fetal development. Associations between both HRs were investigated previously by performing beat-by-beat coupling analysis and correlation analysis between average maternal and fetal HRs. However, studies reporting on the presence of similarities between maternal and fetal HRs or RR intervals (RRIs) over the short term (e.g., 5-min) at different gestational ages (GAs) are scarce. Here, we demonstrate the presence of similarities in the variations exhibited by maternal and fetal RRl tachograms (RRITs). To quantify the same similarities, a cross-correlation (CC) analysis between resampled maternal and fetal RRITs was conducted; RRITs were obtained from non-invasive electrocardiogram (ECG). The degree of similarity between maternal and fetal RRITs (bmfRRITs) was quantified by calculating four CC coefficients. CC analysis was performed for a total of 330 segments (two 5-min segments from 158 subjects and one 5-min from 14 subjects). To investigate the association of the similarity bmfRRITs with fetal development, the linear correlation between the calculated CC coefficients and GA was calculated. The results from the latter analysis showed that similarities bmfRRITs are common occurrences, they can be negative or positive, and they increase with GA suggesting the presence of a regulation that is associated with proper fetal development. To get an insight into the physiological mechanisms involved in the similarity bmfRRITs, the association of the same similarity with maternal and fetal HR variability (HRV) was investigated by comparing the means of two groups in which one of them had higher CC values compared to the other. The two groups were created by using the data from the 158 subjects where fetal RRI (fRRI) calculation from two 5-min ECG segments was feasible. The results of the comparison showed that the maternal very low frequency (VLF) HRV parameter is potentially associated with the similarity bmfRRITs implying that maternal hormones could be linked to the regulations involved in the similarity bmfRRITs. Our findings in this study reinforce the role of the maternal intrauterine environment on fetal development. Frontiers Media S.A. 2022-11-21 /pmc/articles/PMC9721082/ /pubmed/36479345 http://dx.doi.org/10.3389/fphys.2022.964755 Text en Copyright © 2022 Widatalla, Khandoker, Alkhodari, Koide, Yoshida, Kasahara, Kimura and Saito. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Widatalla, Namareq
Khandoker, Ahsan
Alkhodari, Mohanad
Koide, Kunihiro
Yoshida, Chihiro
Kasahara, Yoshiyuki
Kimura, Yoshitaka
Saito, Masatoshi
Similarities between maternal and fetal RR interval tachograms and their association with fetal development
title Similarities between maternal and fetal RR interval tachograms and their association with fetal development
title_full Similarities between maternal and fetal RR interval tachograms and their association with fetal development
title_fullStr Similarities between maternal and fetal RR interval tachograms and their association with fetal development
title_full_unstemmed Similarities between maternal and fetal RR interval tachograms and their association with fetal development
title_short Similarities between maternal and fetal RR interval tachograms and their association with fetal development
title_sort similarities between maternal and fetal rr interval tachograms and their association with fetal development
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721082/
https://www.ncbi.nlm.nih.gov/pubmed/36479345
http://dx.doi.org/10.3389/fphys.2022.964755
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