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Fusion of the β(2)‐adrenergic receptor with either Gαs or βarrestin‐2 produces constitutive signaling by each pathway and induces gain‐of‐function in BEAS‐2B cells

The β(2)AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best‐established signaling pathways for the β(2)AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway. Ex...

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Detalles Bibliográficos
Autores principales:	Lucero‐Garcia Rojas, Emilio Y., Reyes‐Alcaraz, Arfaxad, Ruan, Kehe, McConnell, Bradley K., Bond, Richard A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721090/ https://www.ncbi.nlm.nih.gov/pubmed/36479208 http://dx.doi.org/10.1096/fba.2022-00038

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