Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

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Memory B cells (MBCs) generate rapid antibody responses upon secondary encounter with a pathogen. Here, we investigated the kinetics, avidity, and cross-reactivity of serum antibodies and MBCs in 155 SARS-CoV-2 infected and vaccinated individuals over a 16-month time frame. SARS-CoV-2-specific MBCs...

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Detalles Bibliográficos
Autores principales: Marzi, Roberta, Bassi, Jessica, Silacci-Fregni, Chiara, Bartha, Istvan, Muoio, Francesco, Culap, Katja, Sprugasci, Nicole, Lombardo, Gloria, Saliba, Christian, Cameroni, Elisabetta, Cassotta, Antonino, Low, Jun Siong, Walls, Alexandra C., McCallum, Matthew, Tortorici, M. Alejandra, Bowen, John E., Dellota, Exequiel A., Dillen, Josh R., Czudnochowski, Nadine, Pertusini, Laura, Terrot, Tatiana, Lepori, Valentino, Tarkowski, Maciej, Riva, Agostino, Biggiogero, Maira, Franzetti-Pellanda, Alessandra, Garzoni, Christian, Ferrari, Paolo, Ceschi, Alessandro, Giannini, Olivier, Havenar-Daughton, Colin, Telenti, Amalio, Arvin, Ann, Virgin, Herbert W., Sallusto, Federica, Veesler, David, Lanzavecchia, Antonio, Corti, Davide, Piccoli, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721160/
https://www.ncbi.nlm.nih.gov/pubmed/36507220
http://dx.doi.org/10.1016/j.isci.2022.105726

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