Prognostic analysis of radical resection for iCCA(phl) and iCCA(pps): A retrospective cohort study

BACKGROUD: At present, there is no definitive conclusion about the relative prognostic factors on intrahepatic cholangiocarcinoma perihilar large duct type (iCCA(phl)) and iCCA peripheral small duct type (iCCA(pps)). AIM OF THE STUDY: To compare the prognoses of two different types of iCCA, and identify the independent risk factors affecting the long-term survival of patients undergoing radical resection for iCCA. METHODS: This study included 89 patients with iCCA who underwent radical resection at the Department of Hepatobiliary Surgery of the East Yard of the Shandong Provincial Hospital between January 2013 and March 2022. According to the tumor origin, these patients were divided into the iCCA(phl) group (n = 37) and iCCA(pps) group (n = 52). The prognoses of the two groups were compared using Kaplan–Meier analysis, whereas the independent risk factors of their prognoses were identified using Cox univariate and multivariate regression analyses. RESULTS: In the iCCA(pps) group, the independent risk factors for overall survival included diabetes history (p = 0.006), lymph node metastasis (p = 0.040), and preoperative carbohydrate antigen 19-9 (p = 0.035). In the iCCA(phl) group, the independent risk factors for overall survival included multiple tumors (p = 0.010), tumor differentiation grade (p = 0.008), and preoperative jaundice (p = 0.009). CONCLUSIONS: Among the iCCA patients who underwent radical resection, the long-term prognosis of iCCA(pps) maybe better than that of iCCA(phl). The prognoses of these two types of iCCA were affected by different independent risk factors.