The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism

Myokines are peptides and proteins secreted by skeletal muscle cells, into the interstitium, or in the blood. Their regulation may be dependent or independent of muscle contraction to induce a variety of metabolic effects. Numerous myokines have been implicated in influencing energy metabolism via A...

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Detalles Bibliográficos
Autores principales: Ahsan, Mahdi, Garneau, Léa, Aguer, Céline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721351/
https://www.ncbi.nlm.nih.gov/pubmed/36479347
http://dx.doi.org/10.3389/fphys.2022.1040809
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author Ahsan, Mahdi
Garneau, Léa
Aguer, Céline
author_facet Ahsan, Mahdi
Garneau, Léa
Aguer, Céline
author_sort Ahsan, Mahdi
collection PubMed
description Myokines are peptides and proteins secreted by skeletal muscle cells, into the interstitium, or in the blood. Their regulation may be dependent or independent of muscle contraction to induce a variety of metabolic effects. Numerous myokines have been implicated in influencing energy metabolism via AMP-activated protein kinase (AMPK) signalling. As AMPK is centrally involved in glucose and lipid metabolism, it is important to understand how myokines influence its signalling, and vice versa. Such insight will better elucidate the mechanism of metabolic regulation during exercise and at rest. This review encompasses the latest research conducted on the relationship between AMPK signalling and myokines within skeletal muscles via autocrine or paracrine signalling.
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spelling pubmed-97213512022-12-06 The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism Ahsan, Mahdi Garneau, Léa Aguer, Céline Front Physiol Physiology Myokines are peptides and proteins secreted by skeletal muscle cells, into the interstitium, or in the blood. Their regulation may be dependent or independent of muscle contraction to induce a variety of metabolic effects. Numerous myokines have been implicated in influencing energy metabolism via AMP-activated protein kinase (AMPK) signalling. As AMPK is centrally involved in glucose and lipid metabolism, it is important to understand how myokines influence its signalling, and vice versa. Such insight will better elucidate the mechanism of metabolic regulation during exercise and at rest. This review encompasses the latest research conducted on the relationship between AMPK signalling and myokines within skeletal muscles via autocrine or paracrine signalling. Frontiers Media S.A. 2022-11-21 /pmc/articles/PMC9721351/ /pubmed/36479347 http://dx.doi.org/10.3389/fphys.2022.1040809 Text en Copyright © 2022 Ahsan, Garneau and Aguer. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Ahsan, Mahdi
Garneau, Léa
Aguer, Céline
The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism
title The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism
title_full The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism
title_fullStr The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism
title_full_unstemmed The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism
title_short The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism
title_sort bidirectional relationship between ampk pathway activation and myokine secretion in skeletal muscle: how it affects energy metabolism
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721351/
https://www.ncbi.nlm.nih.gov/pubmed/36479347
http://dx.doi.org/10.3389/fphys.2022.1040809
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