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Birth characteristics and risk of meningioma in a population-based study in California
BACKGROUND: We evaluated the potential role of birth characteristics in the etiology of early-onset meningioma. METHODS: Leveraging a population-based linkage of California birth records (from 1978 to 2015) and cancer registry data (from 1988 to 2015), we identified 362 nonmalignant meningioma cases...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721385/ https://www.ncbi.nlm.nih.gov/pubmed/36479059 http://dx.doi.org/10.1093/noajnl/vdac173 |
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author | Cote, David J Wang, Rong Morimoto, Libby M Metayer, Catherine Stempel, Jessica Zada, Gabriel Ma, Xiaomei Wiemels, Joseph L |
author_facet | Cote, David J Wang, Rong Morimoto, Libby M Metayer, Catherine Stempel, Jessica Zada, Gabriel Ma, Xiaomei Wiemels, Joseph L |
author_sort | Cote, David J |
collection | PubMed |
description | BACKGROUND: We evaluated the potential role of birth characteristics in the etiology of early-onset meningioma. METHODS: Leveraging a population-based linkage of California birth records (from 1978 to 2015) and cancer registry data (from 1988 to 2015), we identified 362 nonmalignant meningioma cases aged 0–37 years and selected 18 100 controls matched on year of birth. Cases and controls were compared with regard to birth characteristics, with adjusted odds ratios (ORs) and 95% confidence intervals (CIs) estimated from unconditional multivariable logistic regression models. We also conducted stratified analyses by race/ethnicity and age. RESULTS: Female sex (compared to male: OR = 1.43, 95% CI: 1.16 to 1.79; P < .01) and Black race (compared to White: OR = 1.46, 95% CI: 1.02 to 2.07; P = .04) were associated with higher risk of meningioma. Higher birth order (OR = 0.90, 95% CI: 0.81 to 0.99 per additional birth position; P = .04) was associated with a lower risk. No significant associations were observed between birthweight, gestational age, delivery mode, maternal age, or maternal education and meningioma risk. In the non-Latino White subgroup, higher birthweight was associated with a higher risk of meningioma (OR = 1.20, 95% CI: 1.02 to 1.41 per 500 grams; P = .03), but this was not recapitulated in the Latino subgroup. In age-stratified analyses, female sex was a risk factor for those diagnosed at the age of 20–37 years but not among younger individuals. CONCLUSIONS: In this large population-based study less prone to selection and recall bias, higher birth order was associated with a reduced risk of early-onset meningioma, while female sex and Black race were linked to an increased risk. There were also indications of differential associations by race/ethnicity and age of diagnosis. |
format | Online Article Text |
id | pubmed-9721385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97213852022-12-06 Birth characteristics and risk of meningioma in a population-based study in California Cote, David J Wang, Rong Morimoto, Libby M Metayer, Catherine Stempel, Jessica Zada, Gabriel Ma, Xiaomei Wiemels, Joseph L Neurooncol Adv Clinical Investigations BACKGROUND: We evaluated the potential role of birth characteristics in the etiology of early-onset meningioma. METHODS: Leveraging a population-based linkage of California birth records (from 1978 to 2015) and cancer registry data (from 1988 to 2015), we identified 362 nonmalignant meningioma cases aged 0–37 years and selected 18 100 controls matched on year of birth. Cases and controls were compared with regard to birth characteristics, with adjusted odds ratios (ORs) and 95% confidence intervals (CIs) estimated from unconditional multivariable logistic regression models. We also conducted stratified analyses by race/ethnicity and age. RESULTS: Female sex (compared to male: OR = 1.43, 95% CI: 1.16 to 1.79; P < .01) and Black race (compared to White: OR = 1.46, 95% CI: 1.02 to 2.07; P = .04) were associated with higher risk of meningioma. Higher birth order (OR = 0.90, 95% CI: 0.81 to 0.99 per additional birth position; P = .04) was associated with a lower risk. No significant associations were observed between birthweight, gestational age, delivery mode, maternal age, or maternal education and meningioma risk. In the non-Latino White subgroup, higher birthweight was associated with a higher risk of meningioma (OR = 1.20, 95% CI: 1.02 to 1.41 per 500 grams; P = .03), but this was not recapitulated in the Latino subgroup. In age-stratified analyses, female sex was a risk factor for those diagnosed at the age of 20–37 years but not among younger individuals. CONCLUSIONS: In this large population-based study less prone to selection and recall bias, higher birth order was associated with a reduced risk of early-onset meningioma, while female sex and Black race were linked to an increased risk. There were also indications of differential associations by race/ethnicity and age of diagnosis. Oxford University Press 2022-11-05 /pmc/articles/PMC9721385/ /pubmed/36479059 http://dx.doi.org/10.1093/noajnl/vdac173 Text en © The Author(s) 2022. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Clinical Investigations Cote, David J Wang, Rong Morimoto, Libby M Metayer, Catherine Stempel, Jessica Zada, Gabriel Ma, Xiaomei Wiemels, Joseph L Birth characteristics and risk of meningioma in a population-based study in California |
title | Birth characteristics and risk of meningioma in a population-based study in California |
title_full | Birth characteristics and risk of meningioma in a population-based study in California |
title_fullStr | Birth characteristics and risk of meningioma in a population-based study in California |
title_full_unstemmed | Birth characteristics and risk of meningioma in a population-based study in California |
title_short | Birth characteristics and risk of meningioma in a population-based study in California |
title_sort | birth characteristics and risk of meningioma in a population-based study in california |
topic | Clinical Investigations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721385/ https://www.ncbi.nlm.nih.gov/pubmed/36479059 http://dx.doi.org/10.1093/noajnl/vdac173 |
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