Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks

Three novel series of N-methylsulfonylindole derivatives 3a&b, 4a–e, and 5a–e were synthesised. Different biological activities of the synthesised compounds were studied. Antimicrobial activity showed that, compounds 4b, 4e and 5d had selective antibacterial activity against the Gram-negative ba...

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Detalles Bibliográficos
Autores principales: Philoppes, John N., Abdelgawad, Mohamed A., Abourehab, Mohammed A. S., Sebak, Mohamed, A. Darwish, Mostafa, Lamie, Phoebe F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721424/
https://www.ncbi.nlm.nih.gov/pubmed/36458373
http://dx.doi.org/10.1080/14756366.2022.2145283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721424/
https://www.ncbi.nlm.nih.gov/pubmed/36458373
http://dx.doi.org/10.1080/14756366.2022.2145283

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