Cargando…

Amino acid variants of SARS-CoV-2 papain-like protease have impact on drug binding

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused both a health and economic crisis around the world. Its papain-like protease (PLpro) is one of the protein targets utilized in designing new drugs that would aid vaccines in the fight against the virus. Although there...

Descripción completa

Detalles Bibliográficos
Autores principales:	Perlinska, Agata P., Stasiulewicz, Adam, Nguyen, Mai Lan, Swiderska, Karolina, Zmudzinski, Mikolaj, Maksymiuk, Alicja W., Drag, Marcin, Sulkowska, Joanna I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721480/ https://www.ncbi.nlm.nih.gov/pubmed/36409737 http://dx.doi.org/10.1371/journal.pcbi.1010667

Ejemplares similares

SARS-CoV-2 Papain-Like Protease Potential Inhibitors—In Silico Quantitative Assessment
por: Stasiulewicz, Adam, et al.
Publicado: (2021)

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design
por: Rut, Wioletta, et al.
Publicado: (2020)

Restriction of S-adenosylmethionine conformational freedom by knotted protein binding sites
por: Perlinska, Agata P., et al.
Publicado: (2020)

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease
por: Patchett, Stephanie, et al.
Publicado: (2021)

Mg(2+)-Dependent Methyl Transfer by a Knotted Protein: A Molecular Dynamics Simulation and Quantum Mechanics Study
por: Perlinska, Agata P., et al.
Publicado: (2020)

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
por: Rut, Wioletta, et al.
Publicado: (2020)

THE REMOVAL OF CARTILAGE MATRIX, IN VIVO, BY PAPAIN : IDENTIFICATION OF CRYSTALLINE PAPAIN PROTEASE AS THE CAUSE OF THE PHENOMENON
por: McCluskey, Robert T., et al.
Publicado: (1958)

Role of Papain-Like Cysteine Proteases in Plant Development
por: Liu, Huijuan, et al.
Publicado: (2018)

A Guide to Targeting the Endocannabinoid System in Drug Design
por: Stasiulewicz, Adam, et al.
Publicado: (2020)

Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities
por: Mielech, Anna M., et al.
Publicado: (2014)

Structural and functional characterization of MERS coronavirus papain-like protease
por: Lin, Min-Han, et al.
Publicado: (2014)

Deubiquitinating Activity of the SARS-CoV Papain-Like Protease
por: Barretto, Naina, et al.
Publicado: (2006)

Targeting papain-like protease for broad-spectrum coronavirus inhibition
por: Yuan, Shuofeng, et al.
Publicado: (2022)

Structure determinants defining the specificity of papain-like cysteine proteases
por: Petushkova, Anastasiia I., et al.
Publicado: (2022)

Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors–Molecular Docking and In Vitro Study
por: Nawrot-Hadzik, Izabela, et al.
Publicado: (2021)

Identification of CB1 Ligands among Drugs, Phytochemicals and Natural-Like Compounds: Virtual Screening and In Vitro Verification
por: Stasiulewicz, Adam, et al.
Publicado: (2022)

Identification of Novel CB2 Ligands through Virtual Screening and In Vitro Evaluation
por: Stasiulewicz, Adam, et al.
Publicado: (2023)

Slipknotted and unknotted monovalent cation-proton antiporters evolved from a common ancestor
por: Zayats, Vasilina, et al.
Publicado: (2021)

Parthenolide reveals an allosteric mode to inhibit the deISGylation activity of SARS-CoV‑2 papain-like protease: Parthenolide covalently inhibits papain-like protease
por: Zou, Zhihui, et al.
Publicado: (2022)

Crystal structure of the Rubella virus protease reveals a unique papain-like protease fold
por: Cheong, Ezekiel Ze Ken, et al.
Publicado: (2022)

Crystal structure of SARS-CoV-2 papain-like protease
por: Gao, Xiaopan, et al.
Publicado: (2021)

SARS-CoV-2 M(pro) Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals
por: Chen, Sizhu Amelia, et al.
Publicado: (2023)

AlphaFold predicts novel human proteins with knots
por: Perlinska, Agata P., et al.
Publicado: (2023)

Nucleolar Essential Protein 1 (Nep1): Elucidation of enzymatic catalysis mechanism by molecular dynamics simulation and quantum mechanics study
por: Jedrzejewski, Mateusz, et al.
Publicado: (2023)

Bacillus anthracis pXO1 plasmid encodes a putative membrane-bound bacteriocin
por: Perlińska, Agata, et al.
Publicado: (2014)

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
por: Klemm, Theresa, et al.
Publicado: (2020)

Papain-Like Proteases as Coronaviral Drug Targets: Current Inhibitors, Opportunities, and Limitations
por: Petushkova, Anastasiia I., et al.
Publicado: (2020)

Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease
por: Clasman, Jozlyn R., et al.
Publicado: (2020)

Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease
por: Lindner, Holger A., et al.
Publicado: (2007)

The papain-like protease of avian infectious bronchitis virus has deubiquitinating activity
por: Yu, Liping, et al.
Publicado: (2017)

Structural and biochemical characterization of SADS‐CoV papain‐like protease 2
por: Wang, Lu, et al.
Publicado: (2020)

In silico Exploration of Inhibitors for SARS-CoV-2's Papain-Like Protease
por: Huynh, Tien, et al.
Publicado: (2021)

Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors
por: Ma, Chunlong, et al.
Publicado: (2022)

The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy
por: Mohamud, Yasir, et al.
Publicado: (2021)

Targeting SARS-CoV-2 papain-like protease in the postvaccine era
por: Ton, Anh-Tien, et al.
Publicado: (2022)

SARS‐CoV‐2 Papain‐Like Protease: Structure, Function and Inhibition
por: Ullrich, Sven, et al.
Publicado: (2022)

Inhibitor induced conformational changes in SARS-COV-2 papain-like protease
por: Ferreira, Glaucio Monteiro, et al.
Publicado: (2022)

Discovery of novel papain-like protease inhibitors for potential treatment of COVID-19
por: Hersi, Fatema, et al.
Publicado: (2023)

Proteases Underground: Analysis of the Maize Root Apoplast Identifies Organ Specific Papain-Like Cysteine Protease Activity
por: Schulze Hüynck, Jan, et al.
Publicado: (2019)

MERS-CoV papain-like protease has deISGylating and deubiquitinating activities
por: Mielech, Anna M., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_r8qc0unppej49spo9g7qjb1394