Cargando…

Whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues

Understanding the neural basis for individual differences in the skin conductance response (SCR) during discriminative fear conditioning may inform on our understanding of autonomic regulation in fear-related psychopathology. Previous region-of-interest (ROI) analyses have implicated the amygdala in...

Descripción completa

Detalles Bibliográficos
Autores principales: Vinberg, Kevin, Rosén, Jörgen, Kastrati, Granit, Ahs, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721615/
https://www.ncbi.nlm.nih.gov/pubmed/36413209
http://dx.doi.org/10.7554/eLife.69686
_version_ 1784843812704616448
author Vinberg, Kevin
Rosén, Jörgen
Kastrati, Granit
Ahs, Fredrik
author_facet Vinberg, Kevin
Rosén, Jörgen
Kastrati, Granit
Ahs, Fredrik
author_sort Vinberg, Kevin
collection PubMed
description Understanding the neural basis for individual differences in the skin conductance response (SCR) during discriminative fear conditioning may inform on our understanding of autonomic regulation in fear-related psychopathology. Previous region-of-interest (ROI) analyses have implicated the amygdala in regulating conditioned SCR, but whole brain analyses are lacking. This study examined correlations between individual differences in SCR during discriminative fear conditioning to social stimuli and neural activity throughout the brain, by using data from a large functional magnetic resonance imaging study of twins (N = 285 individuals). Results show that conditioned SCR correlates with activity in the dorsal anterior cingulate cortex/anterior midcingulate cortex, anterior insula, bilateral temporoparietal junction, right frontal operculum, bilateral dorsal premotor cortex, right superior parietal lobe, and midbrain. A ROI analysis additionally showed a positive correlation between amygdala activity and conditioned SCR in line with previous reports. We suggest that the observed whole brain correlates of SCR belong to a large-scale midcingulo-insular network related to salience detection and autonomic-interoceptive processing. Altered activity within this network may underlie individual differences in conditioned SCR and autonomic aspects of psychopathology.
format Online
Article
Text
id pubmed-9721615
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-97216152022-12-06 Whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues Vinberg, Kevin Rosén, Jörgen Kastrati, Granit Ahs, Fredrik eLife Neuroscience Understanding the neural basis for individual differences in the skin conductance response (SCR) during discriminative fear conditioning may inform on our understanding of autonomic regulation in fear-related psychopathology. Previous region-of-interest (ROI) analyses have implicated the amygdala in regulating conditioned SCR, but whole brain analyses are lacking. This study examined correlations between individual differences in SCR during discriminative fear conditioning to social stimuli and neural activity throughout the brain, by using data from a large functional magnetic resonance imaging study of twins (N = 285 individuals). Results show that conditioned SCR correlates with activity in the dorsal anterior cingulate cortex/anterior midcingulate cortex, anterior insula, bilateral temporoparietal junction, right frontal operculum, bilateral dorsal premotor cortex, right superior parietal lobe, and midbrain. A ROI analysis additionally showed a positive correlation between amygdala activity and conditioned SCR in line with previous reports. We suggest that the observed whole brain correlates of SCR belong to a large-scale midcingulo-insular network related to salience detection and autonomic-interoceptive processing. Altered activity within this network may underlie individual differences in conditioned SCR and autonomic aspects of psychopathology. eLife Sciences Publications, Ltd 2022-11-22 /pmc/articles/PMC9721615/ /pubmed/36413209 http://dx.doi.org/10.7554/eLife.69686 Text en © 2022, Vinberg et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Vinberg, Kevin
Rosén, Jörgen
Kastrati, Granit
Ahs, Fredrik
Whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues
title Whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues
title_full Whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues
title_fullStr Whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues
title_full_unstemmed Whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues
title_short Whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues
title_sort whole brain correlates of individual differences in skin conductance responses during discriminative fear conditioning to social cues
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721615/
https://www.ncbi.nlm.nih.gov/pubmed/36413209
http://dx.doi.org/10.7554/eLife.69686
work_keys_str_mv AT vinbergkevin wholebraincorrelatesofindividualdifferencesinskinconductanceresponsesduringdiscriminativefearconditioningtosocialcues
AT rosenjorgen wholebraincorrelatesofindividualdifferencesinskinconductanceresponsesduringdiscriminativefearconditioningtosocialcues
AT kastratigranit wholebraincorrelatesofindividualdifferencesinskinconductanceresponsesduringdiscriminativefearconditioningtosocialcues
AT ahsfredrik wholebraincorrelatesofindividualdifferencesinskinconductanceresponsesduringdiscriminativefearconditioningtosocialcues