Cargando…
Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome
We aimed to explore the mechanism of the linoleic acid metabolism in metabolic syndrome (MetS). RNA-seq data for 16 samples with or without MetS from the GSE145412 dataset were collected. Gene set variation analysis (GSVA), gene set enrichment analysis (GSEA), and gene differential expression analys...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722286/ https://www.ncbi.nlm.nih.gov/pubmed/36518097 http://dx.doi.org/10.1155/2022/6793346 |
_version_ | 1784843943760887808 |
---|---|
author | Wen, Yan Shang, Yawen Wang, Qing |
author_facet | Wen, Yan Shang, Yawen Wang, Qing |
author_sort | Wen, Yan |
collection | PubMed |
description | We aimed to explore the mechanism of the linoleic acid metabolism in metabolic syndrome (MetS). RNA-seq data for 16 samples with or without MetS from the GSE145412 dataset were collected. Gene set variation analysis (GSVA), gene set enrichment analysis (GSEA), and gene differential expression analysis were performed. Expression data of differentially expressed genes (DEGs) involved in the linoleic acid metabolism pathway were mapped to the pathway by using Pathview for visualization. There were 19 and 10 differentially expressed biological processes in the disease group and healthy group, respectively. 9 KEGG pathways were differentially expressed in the disease group. Linoleic acid metabolism was the only differentially expressed pathway in the healthy group. The GSVA enrichment score of the linoleic acid metabolism pathway in the disease group was markedly lower than that in the healthy group. The GSEA result showed that the linoleic acid metabolism pathway was significantly downregulated in the disease group. JMJD7-PLA2G4B, PLA2G1B, PLA2G2D, CYP2C8, and CYP2J2 involved in the pathway were significantly downregulated in the disease group. This study may provide novel insight into MetS from the point of linoleic acid metabolism dysregulation. |
format | Online Article Text |
id | pubmed-9722286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-97222862022-12-13 Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome Wen, Yan Shang, Yawen Wang, Qing Genet Res (Camb) Research Article We aimed to explore the mechanism of the linoleic acid metabolism in metabolic syndrome (MetS). RNA-seq data for 16 samples with or without MetS from the GSE145412 dataset were collected. Gene set variation analysis (GSVA), gene set enrichment analysis (GSEA), and gene differential expression analysis were performed. Expression data of differentially expressed genes (DEGs) involved in the linoleic acid metabolism pathway were mapped to the pathway by using Pathview for visualization. There were 19 and 10 differentially expressed biological processes in the disease group and healthy group, respectively. 9 KEGG pathways were differentially expressed in the disease group. Linoleic acid metabolism was the only differentially expressed pathway in the healthy group. The GSVA enrichment score of the linoleic acid metabolism pathway in the disease group was markedly lower than that in the healthy group. The GSEA result showed that the linoleic acid metabolism pathway was significantly downregulated in the disease group. JMJD7-PLA2G4B, PLA2G1B, PLA2G2D, CYP2C8, and CYP2J2 involved in the pathway were significantly downregulated in the disease group. This study may provide novel insight into MetS from the point of linoleic acid metabolism dysregulation. Hindawi 2022-11-28 /pmc/articles/PMC9722286/ /pubmed/36518097 http://dx.doi.org/10.1155/2022/6793346 Text en Copyright © 2022 Yan Wen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wen, Yan Shang, Yawen Wang, Qing Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome |
title | Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome |
title_full | Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome |
title_fullStr | Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome |
title_full_unstemmed | Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome |
title_short | Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome |
title_sort | exploration of the mechanism of linoleic acid metabolism dysregulation in metabolic syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722286/ https://www.ncbi.nlm.nih.gov/pubmed/36518097 http://dx.doi.org/10.1155/2022/6793346 |
work_keys_str_mv | AT wenyan explorationofthemechanismoflinoleicacidmetabolismdysregulationinmetabolicsyndrome AT shangyawen explorationofthemechanismoflinoleicacidmetabolismdysregulationinmetabolicsyndrome AT wangqing explorationofthemechanismoflinoleicacidmetabolismdysregulationinmetabolicsyndrome |