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Upregulation of Glutaminyl Cyclase Contributes to ERS-Induced Apoptosis in PC12 Cells

Glutaminyl cyclase (QC) is responsible for converting the N-terminal glutaminyl and glutamyl of the proteins into pyroglutamate (pE) through cyclization. It has been confirmed that QC catalyzes the formation of neurotoxic pE-modified Aβ in the brain of AD patients. But the effects of upregulated QC...

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Detalles Bibliográficos
Autores principales:	Shang, Qi, Yu, Xi, Ouyang, Na, Xu, Pan, Chen, Xiaojie, Wang, Yinan, Li, Chenyang, Wang, Xiaojuan, Lu, Xifeng, Xu, Chenshu, Wu, Haiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722295/ https://www.ncbi.nlm.nih.gov/pubmed/36479306 http://dx.doi.org/10.1155/2022/4154697

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