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Acute Pancreatitis in Childhood: A 10-Year Experience From A Thai University Surgical Center
This study aimed to describe etiology, management, and health outcomes of children developing acute pancreatitis at a tertiary Thailand pediatric surgery center. METHODS: Medical case records of all index cases during 2006–2016 were analyzed and reported. RESULTS: There were 42 male and 37 female pa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722370/ https://www.ncbi.nlm.nih.gov/pubmed/36395407 http://dx.doi.org/10.1097/MPA.0000000000002109 |
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author | Boonthai, Ampaipan Tanpowpong, Pornthep Puttanapitak, Chawintee Aeesoa, Suraida Losty, Paul D. Molagool, Sani |
author_facet | Boonthai, Ampaipan Tanpowpong, Pornthep Puttanapitak, Chawintee Aeesoa, Suraida Losty, Paul D. Molagool, Sani |
author_sort | Boonthai, Ampaipan |
collection | PubMed |
description | This study aimed to describe etiology, management, and health outcomes of children developing acute pancreatitis at a tertiary Thailand pediatric surgery center. METHODS: Medical case records of all index cases during 2006–2016 were analyzed and reported. RESULTS: There were 42 male and 37 female patients, with a mean (standard deviation) age of 10.4 (4.5) years, included in the study. Medications were the commonest etiology for 39.3% of acute pancreatitis attacks, 11.4% for biliary tract disease cases, and 8% for postinterventional studies. In 30% of cases, no cause(s) was defined. Sixty-two patients (78.5%) had elevated serum lipase on hospital admission, whereas only 30.4% showed a raised amylase. Hospital stay was 15 days (interquartile range, 6–27 days). Two major complications in the series were pseudocysts (8.8%) and necrotizing pancreatitis (7.6%). Etiological factors and/or antibiotics were not directly linked to any specific complications. Seventeen children (22.8%) had 1 recurrent episode of acute pancreatitis documented. Mortality rate in index cases was 28%, with a higher percentage harboring a preexisting illness (34.4% vs 5.6%; P = 0.01) and in male than in female patients (41% vs 14%; P = 0.01). CONCLUSIONS: Deaths from pediatric acute pancreatitis are more prevalent in male individuals and those with a preexisting illness. Targeted strategies aimed at “highest-risk” patients may potentially offset mortality. |
format | Online Article Text |
id | pubmed-9722370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-97223702022-12-13 Acute Pancreatitis in Childhood: A 10-Year Experience From A Thai University Surgical Center Boonthai, Ampaipan Tanpowpong, Pornthep Puttanapitak, Chawintee Aeesoa, Suraida Losty, Paul D. Molagool, Sani Pancreas Original Articles This study aimed to describe etiology, management, and health outcomes of children developing acute pancreatitis at a tertiary Thailand pediatric surgery center. METHODS: Medical case records of all index cases during 2006–2016 were analyzed and reported. RESULTS: There were 42 male and 37 female patients, with a mean (standard deviation) age of 10.4 (4.5) years, included in the study. Medications were the commonest etiology for 39.3% of acute pancreatitis attacks, 11.4% for biliary tract disease cases, and 8% for postinterventional studies. In 30% of cases, no cause(s) was defined. Sixty-two patients (78.5%) had elevated serum lipase on hospital admission, whereas only 30.4% showed a raised amylase. Hospital stay was 15 days (interquartile range, 6–27 days). Two major complications in the series were pseudocysts (8.8%) and necrotizing pancreatitis (7.6%). Etiological factors and/or antibiotics were not directly linked to any specific complications. Seventeen children (22.8%) had 1 recurrent episode of acute pancreatitis documented. Mortality rate in index cases was 28%, with a higher percentage harboring a preexisting illness (34.4% vs 5.6%; P = 0.01) and in male than in female patients (41% vs 14%; P = 0.01). CONCLUSIONS: Deaths from pediatric acute pancreatitis are more prevalent in male individuals and those with a preexisting illness. Targeted strategies aimed at “highest-risk” patients may potentially offset mortality. Lippincott Williams & Wilkins 2022-08 2022-11-09 /pmc/articles/PMC9722370/ /pubmed/36395407 http://dx.doi.org/10.1097/MPA.0000000000002109 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Original Articles Boonthai, Ampaipan Tanpowpong, Pornthep Puttanapitak, Chawintee Aeesoa, Suraida Losty, Paul D. Molagool, Sani Acute Pancreatitis in Childhood: A 10-Year Experience From A Thai University Surgical Center |
title | Acute Pancreatitis in Childhood: A 10-Year Experience From A Thai University Surgical Center |
title_full | Acute Pancreatitis in Childhood: A 10-Year Experience From A Thai University Surgical Center |
title_fullStr | Acute Pancreatitis in Childhood: A 10-Year Experience From A Thai University Surgical Center |
title_full_unstemmed | Acute Pancreatitis in Childhood: A 10-Year Experience From A Thai University Surgical Center |
title_short | Acute Pancreatitis in Childhood: A 10-Year Experience From A Thai University Surgical Center |
title_sort | acute pancreatitis in childhood: a 10-year experience from a thai university surgical center |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722370/ https://www.ncbi.nlm.nih.gov/pubmed/36395407 http://dx.doi.org/10.1097/MPA.0000000000002109 |
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