Molecular docking analysis of syringic acid with proteins in inflammatory cascade

Syringic Acid (SA) is a dimethoxybenzene derived from plants. Dietary SA possesses anti-obesity, anti-inflammatory and anti-steatotic effects and is of interest as a potential therapeutic medication in the treatment of obesity, diabetes, diabetic cataracts and asthma. It has anti-tumorigenic effect...

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Autores principales: Sukumaran, Gheena, Ezhilarasan, Devaraj, Ramani, Pratibha, Merlin, R Jancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722417/
https://www.ncbi.nlm.nih.gov/pubmed/36518124
http://dx.doi.org/10.6026/97320630018219
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author Sukumaran, Gheena
Ezhilarasan, Devaraj
Ramani, Pratibha
Merlin, R Jancy
author_facet Sukumaran, Gheena
Ezhilarasan, Devaraj
Ramani, Pratibha
Merlin, R Jancy
author_sort Sukumaran, Gheena
collection PubMed
description Syringic Acid (SA) is a dimethoxybenzene derived from plants. Dietary SA possesses anti-obesity, anti-inflammatory and anti-steatotic effects and is of interest as a potential therapeutic medication in the treatment of obesity, diabetes, diabetic cataracts and asthma. It has anti-tumorigenic effect against hepatocellular carcinoma, lung carcinoma and oral mucosal carcinoma. It is also believed to have a protective effect on Acetaminophen induced damage in Wistar rats. Therefore, it is of interest to document the molecular docking analysis of syringic acid with proteins in inflammatory cascade such as TNF α, NFκB, P50, P65 and IKB for further consideration in drug discovery.
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spelling pubmed-97224172022-12-13 Molecular docking analysis of syringic acid with proteins in inflammatory cascade Sukumaran, Gheena Ezhilarasan, Devaraj Ramani, Pratibha Merlin, R Jancy Bioinformation Research Article Syringic Acid (SA) is a dimethoxybenzene derived from plants. Dietary SA possesses anti-obesity, anti-inflammatory and anti-steatotic effects and is of interest as a potential therapeutic medication in the treatment of obesity, diabetes, diabetic cataracts and asthma. It has anti-tumorigenic effect against hepatocellular carcinoma, lung carcinoma and oral mucosal carcinoma. It is also believed to have a protective effect on Acetaminophen induced damage in Wistar rats. Therefore, it is of interest to document the molecular docking analysis of syringic acid with proteins in inflammatory cascade such as TNF α, NFκB, P50, P65 and IKB for further consideration in drug discovery. Biomedical Informatics 2022-03-31 /pmc/articles/PMC9722417/ /pubmed/36518124 http://dx.doi.org/10.6026/97320630018219 Text en © 2022 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Sukumaran, Gheena
Ezhilarasan, Devaraj
Ramani, Pratibha
Merlin, R Jancy
Molecular docking analysis of syringic acid with proteins in inflammatory cascade
title Molecular docking analysis of syringic acid with proteins in inflammatory cascade
title_full Molecular docking analysis of syringic acid with proteins in inflammatory cascade
title_fullStr Molecular docking analysis of syringic acid with proteins in inflammatory cascade
title_full_unstemmed Molecular docking analysis of syringic acid with proteins in inflammatory cascade
title_short Molecular docking analysis of syringic acid with proteins in inflammatory cascade
title_sort molecular docking analysis of syringic acid with proteins in inflammatory cascade
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722417/
https://www.ncbi.nlm.nih.gov/pubmed/36518124
http://dx.doi.org/10.6026/97320630018219
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AT ramanipratibha moleculardockinganalysisofsyringicacidwithproteinsininflammatorycascade
AT merlinrjancy moleculardockinganalysisofsyringicacidwithproteinsininflammatorycascade

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