FASTK family of genes linked to cancer

Fas Activated Serine/Threonine Kinase (FASTK) family is a protein family encoded in the nuclear genome that spans the mitochondria and executes numerous functions, and consists of FASTK, the founding member along with 5 homologous proteins FASTKD1-5. Up regulation of FASTK family members have not on...

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Autores principales: Ramasubramanian, Abilasha, Paramasivam, A, Ramani, Pratibha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722426/
https://www.ncbi.nlm.nih.gov/pubmed/36518140
http://dx.doi.org/10.6026/97320630018206
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author Ramasubramanian, Abilasha
Paramasivam, A
Ramani, Pratibha
author_facet Ramasubramanian, Abilasha
Paramasivam, A
Ramani, Pratibha
author_sort Ramasubramanian, Abilasha
collection PubMed
description Fas Activated Serine/Threonine Kinase (FASTK) family is a protein family encoded in the nuclear genome that spans the mitochondria and executes numerous functions, and consists of FASTK, the founding member along with 5 homologous proteins FASTKD1-5. Up regulation of FASTK family members have not only been implicated in tumour progression and invasion but also in increased resistance to chemotherapy proven by their knockdown leading to increased sensitivity to drugs. Thus, this review reports the implication of FASTK proteins in cancer and hence provides a scope to emphasise the role of these proteins in Oral Cancer.
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spelling pubmed-97224262022-12-13 FASTK family of genes linked to cancer Ramasubramanian, Abilasha Paramasivam, A Ramani, Pratibha Bioinformation Research Article Fas Activated Serine/Threonine Kinase (FASTK) family is a protein family encoded in the nuclear genome that spans the mitochondria and executes numerous functions, and consists of FASTK, the founding member along with 5 homologous proteins FASTKD1-5. Up regulation of FASTK family members have not only been implicated in tumour progression and invasion but also in increased resistance to chemotherapy proven by their knockdown leading to increased sensitivity to drugs. Thus, this review reports the implication of FASTK proteins in cancer and hence provides a scope to emphasise the role of these proteins in Oral Cancer. Biomedical Informatics 2022-03-31 /pmc/articles/PMC9722426/ /pubmed/36518140 http://dx.doi.org/10.6026/97320630018206 Text en © 2022 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Ramasubramanian, Abilasha
Paramasivam, A
Ramani, Pratibha
FASTK family of genes linked to cancer
title FASTK family of genes linked to cancer
title_full FASTK family of genes linked to cancer
title_fullStr FASTK family of genes linked to cancer
title_full_unstemmed FASTK family of genes linked to cancer
title_short FASTK family of genes linked to cancer
title_sort fastk family of genes linked to cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722426/
https://www.ncbi.nlm.nih.gov/pubmed/36518140
http://dx.doi.org/10.6026/97320630018206
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